Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

• Published in: Proceedings of the National Academy of Sciences - PNAS 2011-04, Vol.108 (17), p.7119-7124
• Main Authors: Schumann, Gunter, Coin, Lachlan J, Lourdusamy, Anbarasu, Charoen, Pimphen, Berger, Karen H, Stacey, David, Desrivières, Sylvane, Aliev, Fazil A, Khan, Anokhi A, Aulchenko, Yurii S, Bakalkin, Georgy, Bakker, Stephan J, Balkau, Beverley, Beulens, Joline W, Bilbao, Ainhoa, de Boer, Rudolf A, Beury, Delphine, Bots, Michiel L, Cauchi, Stéphane, Cavalcanti-Proença, Christine, Chambers, John C, Clarke, Toni-Kim, Dahmen, Norbert, de Geus, Eco J, Dick, Danielle, Ducci, Francesca, Easton, Alanna, Esk, Tõnu, Foroud, Tatiana, Freimer, Nelson B, Girault, Jean-Antoine, Grobbee, Diederick E, Guarrera, Simonetta, Gudbjartsson, Daniel F, Hartikainen, Anna-Liisa, Heath, Andrew C, Hesselbrock, Victor, Hottenga, Jouke-Jan, Kaprio, Jaakko, Khaw, Kay-Tee, Kuehnel, Brigitte, Laitinen, Jaana, Luan, Jian'an, Mangino, Massimo, Maroteaux, Matthieu, Matullo, Giuseppe, Mueller, Christian, Navis, Gerjan, Numans, Mattijs E, Núñez, Alejandro, Nyholt, Dale R, Onland-Moret, Charlotte N, Oostra, Ben A, O'Reilly, Paul F, Palkovits, Miklos, Penninx, Brenda W, Polidoro, Silvia, Pouta, Anneli, Prokopenko, Inga, Ricceri, Fulvio, Santos, Eugenio, Smit, Johannes H, Soranzo, Nicole, Song, Kijoung, Sovio, Ulla, Stumvoll, Michael, Surakk, Ida, Thorgeirsson, Thorgeir E, Thorsteinsdottir, Unnur, Troakes, Claire, Tyrfingsson, Thorarinn, Tönjes, Anke, Uiterwaal, Cuno S, Uitterlinden, Andre G, van der Harst, Pim, van der Schouw, Yvonne T, Staehlin, Oliver, Waeber, Gerard, Wareham, Nicholas J, Wichmann, Erich H, Witteman, Jacqueline C, Yuan, Xin, Zhai, Guangju, Zhao, Jing H, Zhang, Weihua, Martin, Nicholas G, Metspalu, Andres, Doering, Angela, Scott, James, Spector, Tim D, Loos, Ruth J, Boomsma, Dorret I, Peltonen, Leena, van Duijn, Cornelia M, Vineis, Paolo, Kooner, Jaspal S, Spanagel, Rainer, Heberlein, Ulrike A, Jarvelin, Marjo-Riitta, Elliott, Paul
• Format: Article
• Language: English
• Subjects: Alcohol drinking; Alcohol Drinking - genetics; Alcohol Drinking - metabolism; Alcohol use; Alcohols; Alleles; ancestry; Animals; Autism; Behavioral genetics; Biological Sciences; Body weight; Brain; cortex; Cortex (prefrontal); Cytoskeletal Proteins; Drinking behavior; Drosophila; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; epidemiologic; Epidemiology; Ethanol; Female; Gene expression; Gene Expression Regulation - genetics; genes; genome-wide analysis; Genome-Wide Association Study; Genomes; Genotype; Genotype & phenotype; Genotyping; Human genetics; Humans; Male; Medical genetics; Medical research; MEDICIN; MEDICINE; meta-analysis; Mice; Nuclear Proteins - biosynthesis; Nuclear Proteins - genetics; Polymorphism, Single Nucleotide; Proteins - genetics; Proteins - metabolism; Quantitative Trait, Heritable; Replication; Research universities; Rodents; Single-nucleotide polymorphism; Transcription Factors; transcriptional expression analysis; Whites - genetics
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.1017288108

Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of