Born to clot: the European burden

Venous thrombosis is a common problem, predominantly afflicting people of European origin. This European predisposition has been explained to some extent by the recent characterization of factor V Leiden, and the G20210A prothrombin variant. Although it is clear that factor V Leiden is largely confi...

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Bibliographic Details
Published in:British journal of haematology 1999-05, Vol.105 (2), p.564-566
Main Authors: Rees, David C., Chapman, Nicola H., Webster, Matthew T., Guerreiro, Joao F., Rochette, Jacques, Clegg, John B.
Format: Article
Language:English
Subjects:
Africa - ethnology
Americas - ethnology
Asia - ethnology
Australia - ethnology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Factor V - genetics
factor V Leiden
G20210A prothrombin variant
Genetics, Population
Hematology
Heterozygote
Homozygote
Humans
Medical sciences
population genetics
Prothrombin - genetics
thrombophilia
Tropical medicine
venous thrombosis
Venous Thrombosis - ethnology
Venous Thrombosis - genetics
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Summary:Venous thrombosis is a common problem, predominantly afflicting people of European origin. This European predisposition has been explained to some extent by the recent characterization of factor V Leiden, and the G20210A prothrombin variant. Although it is clear that factor V Leiden is largely confined to Europeans, the world distribution of the prothrombin variant is not known. We have analysed samples from 22 different non‐European countries and shown that this prothrombin variant is very rare outside Europe: one case occurring in India. The reason for the confined distribution of these two mutations is unclear.
ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/j.1365-2141.1999.01361.x