Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months: a randomised controlled trial

Objective To investigate the effects of delayed umbilical cord clamping, compared with early clamping, on infant iron status at 4 months of age in a European setting.Design Randomised controlled trial.Setting Swedish county hospital.Participants 400 full term infants born after a low risk pregnancy....

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Bibliographic Details
Published in:BMJ 2011-11, Vol.343 (7836), p.1244-1244
Main Authors: Andersson, Ola, Hellström-Westas, Lena, Andersson, Dan, Domellöf, Magnus
Format: Article
Language:English
Subjects:
Adult
Age
Anemia
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - prevention & control
Anemia, Neonatal - blood
Anemia, Neonatal - prevention & control
Anemia, Neonatal - therapy
Babies
Blood
Blood transfusions
Childbirth & labor
Clinical trials
Clinical Trials (Epidemiology)
Constriction
Delivery, Obstetric
Erythrocyte Indices
Evidence-based medicine
Female
Ferritin
Ferritins
Ferritins - blood
Health care
Health outcomes
Hemoglobin
High income
Humans
Infant, Newborn
Infants
Iron
Iron deficiency
Iron deficiency anemia
Male
Malnutrition
Metabolic Disorders
Metabolism
Midwifery
Neonates
Newborn babies
Nutrient deficiency
Pediatrics
Phototherapy
Physiotherapy
Placenta
Polycythemia - blood
Polycythemia - therapy
Pregnancy
Reproductive Medicine
Sports and Exercise Medicine
Time Factors
Transferrins
Umbilical Cord
Womens health
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Summary:Objective To investigate the effects of delayed umbilical cord clamping, compared with early clamping, on infant iron status at 4 months of age in a European setting.Design Randomised controlled trial.Setting Swedish county hospital.Participants 400 full term infants born after a low risk pregnancy.Intervention Infants were randomised to delayed umbilical cord clamping (≥180 seconds after delivery) or early clamping (≤10 seconds after delivery).Main outcome measures Haemoglobin and iron status at 4 months of age with the power estimate based on serum ferritin levels. Secondary outcomes included neonatal anaemia, early respiratory symptoms, polycythaemia, and need for phototherapy.Results At 4 months of age, infants showed no significant differences in haemoglobin concentration between the groups, but infants subjected to delayed cord clamping had 45% (95% confidence interval 23% to 71%) higher mean ferritin concentration (117 μg/L v 81 μg/L, P
ISSN:0959-8138
0959-8146
0959-535X
1756-1833
1468-5833
1756-1833
DOI:10.1136/bmj.d7157