Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndrome

Growth-differentiation factor-15 (GDF-15) is a member of the transforming growth factor-beta cytokine superfamily that is induced in the heart after ischemia-and-reperfusion injury. Circulating levels of GDF-15 may provide prognostic information in patients with non-ST-elevation acute coronary syndr...

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Published in:Circulation (New York, N.Y.) N.Y.), 2007-02, Vol.115 (8), p.962-971
Main Authors: WOLLERT, Kai C, KEMPF, Tibor, ARMSTRONG, Paul W, CALIFF, Robert M, DREXLER, Helmut, WALLENTIN, Lars, PETER, Timo, OLOFSSON, Sylvia, JAMES, Stefan, JOHNSTON, Nina, LINDAHL, Bertil, HORN-WICHMANN, Rüdiger, BRABANT, Georg, SIMOONS, Maarten L
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Disease
Aged
Biological and medical sciences
Biomarkers
Blood and lymphatic vessels
Blood vessels and receptors
C-Reactive Protein - analysis
Cardiology. Vascular system
Chest Pain - blood
Chest Pain - diagnosis
Chest Pain - mortality
Coronary Disease - blood
Coronary Disease - diagnosis
Coronary Disease - mortality
Coronary heart disease
Cytokines - blood
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Fundamental and applied biological sciences. Psychology
Growth Differentiation Factor 15
Heart
Humans
Male
Medical sciences
MEDICIN
MEDICINE
Middle Aged
Myocardial Infarction - etiology
Prognosis
Recurrence
Vertebrates: cardiovascular system
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Summary:Growth-differentiation factor-15 (GDF-15) is a member of the transforming growth factor-beta cytokine superfamily that is induced in the heart after ischemia-and-reperfusion injury. Circulating levels of GDF-15 may provide prognostic information in patients with non-ST-elevation acute coronary syndrome. Blood samples were obtained on admission from 2081 patients with acute chest pain and either ST-segment depression or troponin elevation who were included in the Global Utilization of Strategies to Open Occluded Arteries (GUSTO)-IV Non-ST-Elevation Acute Coronary Syndrome trial and from a matching cohort of 429 apparently healthy individuals. GDF-15 levels were determined by immunoradiometric assay. Approximately two thirds of patients presented with GDF-15 levels above the upper limit of normal in healthy controls (1200 ng/L); one third presented with levels >1800 ng/L. Increasing tertiles of GDF-15 were associated with an enhanced risk of death at 1 year (1.5%, 5.0%, and 14.1%; P
ISSN:0009-7322
1524-4539
1524-4539
DOI:10.1161/CIRCULATIONAHA.106.650846