Haemodynamic stability and pulmonary shunt during spontaneous breathing and mechanical ventilation in porcine lung collapse

Background We investigated the haemodynamic stability of a novel porcine model of lung collapse induced by negative pressure application (NPA). A secondary aim was to study whether pulmonary shunt correlates with cardiac output (CO). Methods In 12 anaesthetized and relaxed supine piglets, lung colla...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2012-07, Vol.56 (6), p.748-754
Main Authors: VIMLÁTI, L., LARSSON, A., HEDENSTIERNA, G., LICHTWARCK-ASCHOFF, M.
Format: Article
Language:English
Subjects:
Algorithms
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Area Under Curve
Biological and medical sciences
Blood Pressure - physiology
Cardiac Output - physiology
Continuous Positive Airway Pressure
Heart Rate - physiology
Hemodynamics - physiology
Medical sciences
Positive-Pressure Respiration
Pulmonary arteries
Pulmonary Atelectasis - physiopathology
Pulmonary Gas Exchange
Pulmonary Wedge Pressure - physiology
Respiration
Respiration, Artificial
Stroke Volume - physiology
Swine
Thermodilution
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Summary:Background We investigated the haemodynamic stability of a novel porcine model of lung collapse induced by negative pressure application (NPA). A secondary aim was to study whether pulmonary shunt correlates with cardiac output (CO). Methods In 12 anaesthetized and relaxed supine piglets, lung collapse was induced by NPA (−50 kPa). Six animals resumed spontaneous breathing (SB) after 15 min; the other six animals were kept on mechanical ventilation (MV) at respiratory rate and tidal volume (VT) that corresponded to SB. All animals were followed for 135 min with blood gas analysis and detailed haemodynamic monitoring. Results Haemodynamics and gas exchange were stable in both groups during the experiment with arterial oxygen tension (PaO2)/inspired fraction of oxygen (FiO2) and pulmonary artery occlusion pressure being higher, venous admixture (Qva/Qt) and pulmonary perfusion pressure being lower in the SB group. CO was similar in both groups, showing slight decrease over time in the SB group. During MV, Qva/Qt increased with CO (slope: 4.3 %min/l; P 
ISSN:0001-5172
1399-6576
1399-6576
DOI:10.1111/j.1399-6576.2012.02700.x