Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases

Highlights ► The neuromuscular junction (NMJ) as a highly reliable synapse. ► Formation and maintenance of the NMJ as a coordinated and interactive process. ► Autoantibodies against NMJ receptors cause myasthenia gravis with muscle weakness. ► Mutations in genes encoding NMJ proteins cause congenita...

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Bibliographic Details
Published in:Current opinion in pharmacology 2012-06, Vol.12 (3), p.340-346
Main Authors: Punga, Anna Rostedt, Ruegg, Markus A
Format: Article
Language:English
Subjects:
Adrenergic beta-2 Receptor Agonists - adverse effects
Adrenergic beta-2 Receptor Agonists - pharmacology
Adrenergic beta-2 Receptor Agonists - therapeutic use
Adult
Aging - metabolism
Animals
Child
Humans
Internal Medicine
Medical Education
Muscle Development
Neurogenesis
Neuromuscular Junction - drug effects
Neuromuscular Junction - growth & development
Neuromuscular Junction - metabolism
Neuromuscular Junction - physiopathology
Neuromuscular Junction Diseases - drug therapy
Neuromuscular Junction Diseases - immunology
Neuromuscular Junction Diseases - metabolism
Neuromuscular Junction Diseases - physiopathology
Receptors, Cholinergic - metabolism
Sarcopenia - drug therapy
Sarcopenia - metabolism
Sarcopenia - physiopathology
Signal Transduction - drug effects
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Summary:Highlights ► The neuromuscular junction (NMJ) as a highly reliable synapse. ► Formation and maintenance of the NMJ as a coordinated and interactive process. ► Autoantibodies against NMJ receptors cause myasthenia gravis with muscle weakness. ► Mutations in genes encoding NMJ proteins cause congenital myasthenic syndrome. ► Fragmentation of the NMJ contributes to sarcopenia, the muscle loss with aging.
ISSN:1471-4892
1471-4973
1471-4973
DOI:10.1016/j.coph.2012.02.002