Measurements of Brownian relaxation of magnetic nanobeads using planar Hall effect bridge sensors

We compare measurements of the Brownian relaxation response of magnetic nanobeads in suspension using planar Hall effect sensors of cross geometry and a newly proposed bridge geometry. We find that the bridge sensor yields six times as large signals as the cross sensor, which results in a more accur...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2013-02, Vol.40 (1), p.147-152
Main Authors: Østerberg, F.W., Rizzi, G., Zardán Gómez de la Torre, T., Strömberg, M., Strømme, M., Svedlindh, P., Hansen, M.F.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopolymers - analysis
Biosensing Techniques - instrumentation
Biosensor
Biosensors
Biotechnology
Brownian relaxometry
Conductometry - instrumentation
Diffusion
Engineering Science with specialization in Nanotechnology and Functional Materials
Engineering Science with specialization in Solid State Physics
Equipment Design
Equipment Failure Analysis
Fundamental and applied biological sciences. Psychology
Immunomagnetic Separation - instrumentation
Lab-on-a-chip
Magnetic nanobeads
Magnetic sensor
Magnetics - instrumentation
Magnetorelaxometry
Methods. Procedures. Technologies
Reproducibility of Results
Sensitivity and Specificity
TECHNOLOGY
TEKNIKVETENSKAP
Teknisk fysik med inriktning mot fasta tillståndets fysik
Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Various methods and equipments
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Description
Summary:We compare measurements of the Brownian relaxation response of magnetic nanobeads in suspension using planar Hall effect sensors of cross geometry and a newly proposed bridge geometry. We find that the bridge sensor yields six times as large signals as the cross sensor, which results in a more accurate determination of the hydrodynamic size of the magnetic nanobeads. Finally, the bridge sensor has successfully been used to measure the change in dynamic magnetic response when rolling circle amplified DNA molecules are bound to the magnetic nanobeads. The change is validated by measurements performed in a commercial AC susceptometer. The presented bridge sensor is, thus, a promising component in future lab-on-a-chip biosensors for detection of clinically relevant analytes, including bacterial genomic DNA and proteins.
ISSN:0956-5663
1873-4235
1873-4235
DOI:10.1016/j.bios.2012.07.002