Organic Selenium Supplementation Increases Mercury Excretion and Decreases Oxidative Damage in Long-Term Mercury-Exposed Residents from Wanshan, China

Due to a long history of extensive mercury mining and smelting activities, local residents in Wanshan, China, are suffering from elevated mercury exposure. The objective of the present study was to study the effects of oral supplementation with selenium-enriched yeast in these long-term mercury-expo...

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Bibliographic Details
Published in:Environmental science & technology 2012-10, Vol.46 (20), p.11313-11318
Main Authors: Li, Yu-Feng, Dong, Zeqin, Chen, Chunying, Li, Bai, Gao, Yuxi, Qu, Liya, Wang, Tianchen, Fu, Xin, Zhao, Yuliang, Chai, Zhifang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antioxidants - pharmacology
Biological and medical sciences
Biomarkers - metabolism
Chemical and industrial products toxicology. Toxic occupational diseases
China
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
Dietary Supplements
Environmental Pollutants - metabolism
Environmental Pollutants - toxicity
Environmental Pollutants - urine
Female
Food Contamination - statistics & numerical data
Human exposure
Humans
Male
Malondialdehyde - metabolism
Medical sciences
Mercury
Mercury - metabolism
Mercury - toxicity
Mercury - urine
Metals and various inorganic compounds
Middle Aged
Mining
Oxidative stress
Oxidative Stress - drug effects
Selenium
Selenium - pharmacology
Toxicology
Yeast
Young Adult
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Summary:Due to a long history of extensive mercury mining and smelting activities, local residents in Wanshan, China, are suffering from elevated mercury exposure. The objective of the present study was to study the effects of oral supplementation with selenium-enriched yeast in these long-term mercury-exposed populations. One hundred and three volunteers from Wanshan area were recruited and 53 of them were supplemented with 100 μg of organic selenium daily as selenium-enriched yeast while 50 of them were supplemented with the nonselenium-enriched yeast for 3 months. The effects of selenium supplementation on urinary mercury, selenium, and oxidative stress-related biomarkers including malondialdehyde and 8-hydroxy-2-deoxyguanosine were assessed. This 3-month selenium supplementation trial indicated that organic selenium supplementation could increase mercury excretion and decrease urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine levels in local residents.
ISSN:0013-936X
1520-5851
1520-5851
DOI:10.1021/es302241v