Non-Enzymatic Dynamic Kinetic Resolution of Secondary Aryl Alcohols: Planar Chiral Ferrocene and Ruthenium Catalysts in Cooperation

“Ruth” helps iron! A novel method for the non‐enzymatic dynamic kinetic resolution (DKR) of secondary aryl alcohols by the use of the planar chiral ferrocene derivative (+)‐1 in combination with the ruthenium racemization catalyst 2 yields acetylated alcohols in high enantioselectivity and yield. Th...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-01, Vol.52 (2), p.502-504
Main Authors: Díaz-Álvarez, Alba E., Mesas-Sánchez, Laura, Dinér, Peter
Format: Article
Language:English
Subjects:
Acylation
Alcohols
Alcohols - chemistry
Aromatic compounds
Catalysis
Catalysts
chiral resolution
Dynamics
Ferrocenes
Ferrous Compounds - chemical synthesis
Ferrous Compounds - chemistry
kinetic resolution
Kinetics
Metallocenes
Molecular Dynamics Simulation
Molecular Structure
Reaction kinetics
Ruthenium
Ruthenium - chemistry
secondary alcohols
Stereoisomerism
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Summary:“Ruth” helps iron! A novel method for the non‐enzymatic dynamic kinetic resolution (DKR) of secondary aryl alcohols by the use of the planar chiral ferrocene derivative (+)‐1 in combination with the ruthenium racemization catalyst 2 yields acetylated alcohols in high enantioselectivity and yield. This development opens opportunities for new developments in the field of non‐enzymatic dynamic kinetic resolution.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201207648