Fractional exhaled nitric oxide in Chinese children with asthma and allergies–A two-city study

Summary Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker of eosinophilic airway inflammation. Our aim was to study associations between FeNO in Chinese children in two cities and asthma, asthmatic symptoms, rhinitis, eczema, and selected childhood and home environmental factors. A...

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Bibliographic Details
Published in:Respiratory medicine 2013-02, Vol.107 (2), p.161-171
Main Authors: Zhao, Zhuohui, Huang, Chen, Zhang, Xin, Xu, Feng, Kan, Haidong, Song, Weimin, Wieslander, Gunilla, Norback, Dan
Format: Article
Language:English
Subjects:
Adolescent
Air Pollutants - adverse effects
Air Pollutants - analysis
Air pollution
Air Pollution - adverse effects
Air Pollution - analysis
Airway inflammation
Allergic rhinitis
Allergies
Asthma
Asthma - diagnosis
Asthma - epidemiology
Asthma - etiology
Biological and medical sciences
Biomarkers - analysis
Breath Tests - methods
Child
Children & youth
China
China - epidemiology
Chronic obstructive pulmonary disease, asthma
Cross-Sectional Studies
Dermatitis, Atopic - epidemiology
Dermatitis, Atopic - etiology
Environmental Monitoring - methods
Female
Humans
Male
Medical Science
Medical sciences
Medicinsk vetenskap
Nitric Oxide - analysis
Non tumoral diseases
Otorhinolaryngology. Stomatology
Pneumology
Pulmonary/Respiratory
Residence Characteristics
Respiratory Sounds - etiology
Rhinitis, Allergic, Perennial - epidemiology
Rhinitis, Allergic, Perennial - etiology
Rhinitis, Allergic, Seasonal - epidemiology
Rhinitis, Allergic, Seasonal - etiology
Risk Factors
Sex Factors
Studies
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Summary Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker of eosinophilic airway inflammation. Our aim was to study associations between FeNO in Chinese children in two cities and asthma, asthmatic symptoms, rhinitis, eczema, and selected childhood and home environmental factors. A random sample of children in Shanghai ( n  = 187) and Taiyuan ( n  = 127), and additional randomly selected children reporting current wheeze ( n  = 115) were invited for FeNO measurements by NIOX MINO. A questionnaire survey was performed among all subjects (12–14 y) in 59 classes in Shanghai and 44 in Taiyuan. Associations were studied using multiple linear regression using 10log transformed FeNO data and mutual adjustment. The geometric mean FeNO in the random sample (GM ± GSD) was higher in Shanghai (16.2 ± 1.9 ppb) as compared to Taiyuan (12.8 ± 1.6 ppb) ( P  
ISSN:0954-6111
1532-3064
1532-3064
DOI:10.1016/j.rmed.2012.11.001