Prognostic Usefulness of the Change in N-terminal pro B-type Natriuretic Peptide Levels to Predict Mortality in a Single Community Cohort Aged ≥70 Years

• Published in: The American journal of cardiology 2013, Vol.111 (1), p.131-136
• Main Authors: Eggers, Kai M., MD, PhD, Venge, Per, MD, PhD, Lind, Lars, MD, PhD
• Format: Article
• Language: English
• Subjects: Aged; Biomarkers - blood; Cardiovascular; Cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - mortality; Cholesterol; Female; Follow-Up Studies; Heart attacks; Humans; Immunoenzyme Techniques; Male; Mortality; Natriuretic Peptide, Brain - blood; Older people; Peptide Fragments - blood; Predictive Value of Tests; Prognosis; Prospective Studies; Protein Precursors; Risk Assessment - methods; Risk Factors; Studies; Survival Rate - trends; Sweden - epidemiology
• ISSN: 0002-9149; 1879-1913; 1879-1913
• DOI: 10.1016/j.amjcard.2012.08.058

The levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) are closely related to cardiac abnormalities and adverse outcomes in the general population. However, little is known about the course of NT-proBNP levels over time, the underlying conditions, and the prognostic effect of changes. To investigate these issues, we measured the NT-proBNP levels (Elecsys 2010, Roche Diagnostics) in community-dwellers participating in the Prospective Investigation of the Vasculature in Uppsala Seniors study at 70 (n = 1,005) and 75 (n = 817) years of age. The total follow-up was 8.0 years. In subjects with available results from both examinations, the median NT-proBNP levels increased from 106 pg/ml (25th to 75th percentile 62 to 174) to 125 pg/ml (25th to 75th percentile 73-234; p