Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in adults 70 years of age and older previously vaccinated with 23-valent pneumococcal polysaccharide vaccine

Highlights • Free polysaccharide pneumococcal vaccine is generally recommended for older adults. • Conjugate and free polysaccharide vaccines were compared in pre-immunized adults. • Conjugate responses were significantly greater for majority of serotypes. • Conjugate vaccine did not negatively infl...

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Bibliographic Details
Published in:Vaccine 2013-08, Vol.31 (35), p.3585-3593
Main Authors: Jackson, Lisa A, Gurtman, Alejandra, Rice, Kathryn, Pauksens, Karlis, Greenberg, Richard N, Jones, Thomas R, Scott, Daniel A, Emini, Emilio A, Gruber, William C, Schmoele-Thoma, Beate
Format: Article
Language:English
Subjects:
Adults
Age
Aged
Aged, 80 and over
Alcoholism
Allergy and Immunology
Antibodies, Bacterial - blood
Applied microbiology
Bacteriology
Biological and medical sciences
Disease
Double-Blind Method
elderly
Family medical history
Female
Fever
Fundamental and applied biological sciences. Psychology
Geriatrics
HIV
Human immunodeficiency virus
Humans
immune response
Immunization, Secondary
Immunogenicity
Male
Microbiology
Miscellaneous
Muscle pain
Objectives
Older people
PCV13
Pneumococcal conjugate vaccine
Pneumococcal Vaccines - adverse effects
Pneumococcal Vaccines - immunology
Pneumococcal Vaccines - therapeutic use
Pneumonia, Pneumococcal - immunology
Pneumonia, Pneumococcal - prevention & control
Polysaccharides, Bacterial - immunology
serotypes
Streptococcus pneumoniae
Streptococcus pneumoniae - immunology
United States
vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Conjugate - adverse effects
Vaccines, Conjugate - immunology
Vaccines, Conjugate - therapeutic use
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Summary:Highlights • Free polysaccharide pneumococcal vaccine is generally recommended for older adults. • Conjugate and free polysaccharide vaccines were compared in pre-immunized adults. • Conjugate responses were significantly greater for majority of serotypes. • Conjugate vaccine did not negatively influence response to follow-on dose at 1 year. • Free polysaccharide vaccine diminished response to follow-on conjugate at 1 year.
ISSN:0264-410X
1873-2518
1873-2518
DOI:10.1016/j.vaccine.2013.05.010