Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

Purpose In the present study, we screened a compound library containing 1,600 clinically used compounds with the aim to identify compounds, which potentially could be repositioned for colon cancer therapy. Methods Two established colon cancer cell lines were tested using the fluorometric microcultur...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2013-12, Vol.139 (12), p.2133-2140
Main Authors: Nygren, Peter, Fryknäs, Mårten, Ågerup, Bengt, Larsson, Rolf
Format: Article
Language:English
Subjects:
Anthelmintics - pharmacology
Anthelmintics - therapeutic use
Antineoplastic agents
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Benzimidazoles
Biological and medical sciences
Cancer Research
Cell Survival - drug effects
Colon cancer
Colonic Neoplasms - drug therapy
Colonic Neoplasms - genetics
Colonic Neoplasms - pathology
Colorectal cancer
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Drug Repositioning
Drugs
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression Regulation, Neoplastic - drug effects
HCT116 Cells
Hematology
HT29 Cells
Humans
Internal Medicine
Mebendazole
Mebendazole - pharmacology
Mebendazole - therapeutic use
Medical sciences
Medicine
Medicine & Public Health
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Oncology
Pharmacology. Drug treatments
Rapid Communication
Repositioning
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Therapy
Tumor Cells, Cultured
Tumors
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Summary:Purpose In the present study, we screened a compound library containing 1,600 clinically used compounds with the aim to identify compounds, which potentially could be repositioned for colon cancer therapy. Methods Two established colon cancer cell lines were tested using the fluorometric microculture cytotoxicity assay (FMCA). For compound comparison connectivity map (CMAP) analysis, NCI 60 data mining and protein kinase binding measurements were performed. Results Sixty-eight compounds were defined as hits with activity in both of these cell lines (
ISSN:0171-5216
1432-1335
1432-1335
DOI:10.1007/s00432-013-1539-5