Imaging of HER2 may improve the outcome of external irradiation therapy for prostate cancer patients

Prostate cancer (PCa) is the most common type of cancer among males. Human epidermal growth factor receptor type 2 (HER2) expression in PCa has been reported by several studies and its involvement in the progression towards androgen-independent PCa has been discussed. External irradiation is one of...

Full description

Saved in:
Bibliographic Details
Published in:Oncology letters 2015-02, Vol.9 (2), p.950-954
Main Authors: ANDERSSON, JENNIE, ROSESTEDT, MARIA, ORLOVA, ANNA
Format: Article
Language:English
Subjects:
Androgens
Apoptosis
Cancer therapies
Care and treatment
Cell division
Cell receptors
Drug dosages
external irradiation
Genetic aspects
Health aspects
human epidermal growth factor receptor type 2
Metastasis
molecular imaging
Monoclonal antibodies
Oncology
Patient outcomes
Patients
Prostate cancer
Radiotherapy
Studies
Targeted cancer therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prostate cancer (PCa) is the most common type of cancer among males. Human epidermal growth factor receptor type 2 (HER2) expression in PCa has been reported by several studies and its involvement in the progression towards androgen-independent PCa has been discussed. External irradiation is one of the existing therapies, which has been demonstrated to be efficient in combination with androgen deprivation therapy for the treatment of advanced PCa. However, 20-40% of patients develop recurrent and more aggressive PCa within 10 years. The current study investigates the involvement of HER2 in survival and radioresistance in PCa cells and we hypothesized that, by monitoring HER2 expression, treatment may be personalized. The PCa cell lines, LNCap, PC3 and DU-145, received a 6 Gy single dose of external irradiation. The number of PC3 cells was not affected by a single dose of radiation, whereas a 5-fold decrease in cell number was detected in LNCap (P
ISSN:1792-1074
1792-1082
1792-1082
DOI:10.3892/ol.2014.2760