Oral anticoagulation: a critique of recent advances and controversies

Highlights • Warfarin is the most commonly used oral anticoagulant for thrombotic disorders. • Genotype-guided dosing of warfarin may have clinical utility. • New oral anticoagulants have benefits, as well as drawbacks. • Methods are needed for stratification between the new and established anticoag...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2015-03, Vol.36 (3), p.153-163
Main Authors: Pirmohamed, Munir, Kamali, Farhad, Daly, Ann K, Wadelius, Mia
Format: Article
Language:English
Subjects:
Administration, Oral
Advanced Basic Science
algorithm
Algorithms
Anticoagulants - administration & dosage
Anticoagulants - pharmacology
Anticoagulants - therapeutic use
Dose-Response Relationship, Drug
Genotype
Humans
oral anticoagulant
pharmacogenomics
Vitamin K - antagonists & inhibitors
vitamin K antagonist
warfarin
Warfarin - administration & dosage
Warfarin - pharmacology
Warfarin - therapeutic use
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Summary:Highlights • Warfarin is the most commonly used oral anticoagulant for thrombotic disorders. • Genotype-guided dosing of warfarin may have clinical utility. • New oral anticoagulants have benefits, as well as drawbacks. • Methods are needed for stratification between the new and established anticoagulants.
ISSN:0165-6147
1873-3735
1873-3735
DOI:10.1016/j.tips.2015.01.003