Rapid and Accurate MRI Segmentation of Peritumoral Brain Edema in Meningiomas

• Published in: Clinical neuroradiology (Munich) 2017-06, Vol.27 (2), p.145-152
• Main Authors: Latini, F., Larsson, E.-M., Ryttlefors, M.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Brain cancer; Brain Edema - diagnostic imaging; Brain Edema - pathology; Brain tumors; Cerebral edema; Diffusion Magnetic Resonance Imaging - methods; Edema; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Machine Learning; Magnetic resonance imaging; Male; Medicine; Medicine & Public Health; Meningeal Neoplasms - diagnostic imaging; Meningeal Neoplasms - pathology; Meningioma - diagnostic imaging; Meningioma - pathology; Middle Aged; Neurokirurgi; Neurology; Neuroradiology; Neurosurgery; Original Article; Pattern Recognition, Automated - methods; Reproducibility of Results; Sensitivity and Specificity
• ISSN: 1869-1439; 1869-1447; 1869-1447
• DOI: 10.1007/s00062-015-0481-0

Purpose The extent of peritumoral brain edema (PTBE) in meningiomas commonly affects the clinical outcome. Despite its importance, edema volume is usually highly inaccurately approximated to a spheroid shape. We tested the accuracy and the reproducibility of semiautomatic lesion management software for the analysis of PTBE in a homogeneous case series of surgically confirmed intracranial meningiomas. Methods PTBE volume was calculated on magnetic resonance images in 50 patients with intracranial meningiomas using commercial lesion management software (Vue PACS Livewire, Carestream, Rochester, NY, USA). Inter and intraobserver agreement evaluation and a comparison between manual volume calculation, the semiautomatic software and spheroid approximation were performed in 22 randomly selected patients. Results The calculation of edema volume was possible in all cases irrespective of the extent of the signal changes. The median time for each calculation was 3 min. Interobserver and intraobserver agreement confirmed the reproducibility of the method. Comparison with standard (fully manual) calculation confirmed the accuracy of this software. Conclusions Our study showed a high level of reproducibility of this semiautomatic computational method for peritumoral brain edema. It is rapid and easy to use after relatively short training and is suitable for implementation in clinical practice.