Factors impeding the discovery of an intervention‐based treatment for type 1 diabetes

Summary Type 1 diabetes (T1D) is one of the most common and severe chronic diseases affecting both children and adults. The aetiology of the disease remains unknown, and thus far no ‘true’ cure for those affected is available. Indeed, exogenous insulin replacement therapy to manage glucose metabolis...

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Bibliographic Details
Published in:Clinical and experimental immunology 2016-01, Vol.183 (1), p.1-7
Main Authors: von Herrath, M. G., Korsgren, O., Atkinson, M. A.
Format: Article
Language:English
Subjects:
Adult
Animals
autoimmune disease
beta cells
Blood Glucose - metabolism
Child
Diabetes Mellitus, Type 1 - therapy
Humans
Hypoglycemic Agents - therapeutic use
immune therapy
insulin
Insulin - therapeutic use
Pancreas - metabolism
Pancreas - pathology
Translational Research, Biomedical
type 1 diabetes
Type 1 Diabetes Mini‐series: Pathogenesis and Therapy
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Summary:Summary Type 1 diabetes (T1D) is one of the most common and severe chronic diseases affecting both children and adults. The aetiology of the disease remains unknown, and thus far no ‘true’ cure for those affected is available. Indeed, exogenous insulin replacement therapy to manage glucose metabolism to the best degree possible remains the current standard of care. However, despite a recent array of truly impressive improvements designed to enhance disease management (e.g. insulin analogues, continuous glucose monitoring, insulin pumps), it is still difficult for the vast majority of patients to reach recommended target HbA1C levels (
ISSN:0009-9104
1365-2249
1365-2249
DOI:10.1111/cei.12656