Characterization of the γ-aminobutyric acid signaling system in the zebrafish ( Danio rerio Hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction

• Published in: Neuroscience 2017-02, Vol.343, p.300-321
• Main Authors: Cocco, Arianna, Carolina Rönnberg, A.M, Jin, Zhe, André, Gonçalo Igreja, Vossen, Laura E, Bhandage, Amol K, Thörnqvist, Per-Ove, Birnir, Bryndis, Winberg, Svante
• Format: Article
• Language: English
• Subjects: Amino Acid Sequence; Animals; Brain - metabolism; comparative neuroscience; Fish Proteins - genetics; Fish Proteins - metabolism; GABA; GABA Plasma Membrane Transport Proteins - genetics; GABA Plasma Membrane Transport Proteins - metabolism; gamma-Aminobutyric Acid - metabolism; Gene Expression; Neurology; neurotransmitter systems; Protein Isoforms; receptors; Receptors, GABA-A - genetics; Receptors, GABA-A - metabolism; Receptors, GABA-B - genetics; Receptors, GABA-B - metabolism; Retina - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Sequence Alignment; Sequence Homology, Amino Acid; teleost; zebrafish; Zebrafish - metabolism
• ISSN: 0306-4522; 1873-7544; 1873-7544
• DOI: 10.1016/j.neuroscience.2016.07.018

Highlights • Zebrafish brains and retinas express the genes for GABA signaling. • The GABA system depicts regional brain differences. • The zebrafish GABA system shares similarities with that of mammals. • Zebrafish, as mammals, splice the γ2 subunit of the GABAA receptor. • The GABAA receptor α6a , α6b genes are tissue-specifically expressed.