Permeability-increasing ability of PAF-acether in rat skin

Platelet-activating factor (PAF-acether), a phospholipid compound with effects on several cells, e.g., platelets and polymorphonuclear leukocytes (PMNs), was examined for its effect on microvascular permeability in rat skin. It was found to increase microvascular permeability, measured as exudation...

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Bibliographic Details
Published in:Inflammation 1985-03, Vol.9 (1), p.107-112
Main Authors: GERDIN, B, LUNDBERG, C, SMEDEGARD, G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Capillary Permeability - drug effects
Cell Membrane Permeability
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Histamine - pharmacology
Inflammation
Male
Molecular and cellular biology
Neutrophils - cytology
Platelet Activating Factor - pharmacology
Rats
Rats, Inbred Strains
Skin - drug effects
Zymosan - pharmacology
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Summary:Platelet-activating factor (PAF-acether), a phospholipid compound with effects on several cells, e.g., platelets and polymorphonuclear leukocytes (PMNs), was examined for its effect on microvascular permeability in rat skin. It was found to increase microvascular permeability, measured as exudation of [125I]human serum albumin, in amounts exceeding 1 pmol, and was more than 1000 times as potent as histamine. The effect was independent of cell infiltration, as no accumulation of PMNs, measured as the amount of myeloperoxidase in the skin, occurred and as the response was unaltered in animals rendered neutropenic due to treatment with an antiserum against PMNs.
ISSN:0360-3997
1573-2576
1573-2576
DOI:10.1007/BF00915417