The human protein atlas: A spatial map of the human proteome

The correct spatial distribution of proteins is vital for their function and often mis‐localization or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas (HPA) has constituted a valuable tool for researchers studying protein localization and expression in human tis...

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Bibliographic Details
Published in:Protein science 2018-01, Vol.27 (1), p.233-244
Main Authors: Thul, Peter J., Lindskog, Cecilia
Format: Article
Language:English
Subjects:
antibodies
Databases, Protein
Ectopic expression
Gene Expression Regulation
Human tissues
Humans
Immunocytochemistry
immunofluorescence
Immunohistochemistry
Localization
protein expression
Proteins
Proteome - biosynthesis
Proteome - chemistry
Proteome - genetics
Proteomics
single-cell
Spatial distribution
spatial proteomics
Tissues
Tools for Protein Science
transcriptomics
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Summary:The correct spatial distribution of proteins is vital for their function and often mis‐localization or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas (HPA) has constituted a valuable tool for researchers studying protein localization and expression in human tissues and cells. The centerpiece of the HPA is its unique antibody collection for mapping the entire human proteome by immunohistochemistry and immunocytochemistry. By these approaches, more than 10 million images showing protein expression patterns at a single‐cell level were generated and are publicly available at www.proteinatlas.org. The antibody‐based approach is combined with transcriptomics data for an overview of global expression profiles. The present article comprehensively describes the HPA database functions and how users can utilize it for their own research as well as discusses the future path of spatial proteomics.
ISSN:0961-8368
1469-896X
1469-896X
DOI:10.1002/pro.3307