Association between HbA 1c and peripheral neuropathy in a 10-year follow-up study of people with normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes

• Published in: Diabetic medicine 2017-12, Vol.34 (12), p.1756-1764
• Main Authors: Peterson, M, Pingel, R, Lagali, N, Dahlin, L B, Rolandsson, O
• Format: Article
• Language: English
• Subjects: Aged; Blood Glucose - metabolism; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetic Neuropathies - blood; Diabetic Neuropathies - epidemiology; Female; Follow-Up Studies; Glucose Intolerance - blood; Glucose Intolerance - epidemiology; Glucose Tolerance Test; Glycated Hemoglobin A - metabolism; Humans; Male; Middle Aged; Risk Factors; Sweden - epidemiology
• ISSN: 0742-3071; 1464-5491; 1464-5491
• DOI: 10.1111/dme.13514

To explore the association between HbA and sural nerve function in a group of people with normal glucose tolerance, impaired glucose tolerance or Type 2 diabetes. We conducted a 10-year follow-up study in 87 out of an original 119 participants. At study commencement (2004), 64 men and 55 women (mean age 61.1 years) with normal glucose tolerance (n=39), impaired glucose tolerance (n=29), or Type 2 diabetes (n=51) were enrolled. At the 2014 follow-up (men, n=46, women, n=41; mean age 71.1 years), 36, nine and 42 participants in the normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes categories, respectively, were re-tested. Biometric data and blood samples were collected, with an electrophysiological examination performed on both occasions. At follow-up, we measured the amplitude of the sural nerve in 74 of the 87 participants. The mean amplitude had decreased from 10.9 μV (2004) to 7.0 μV (2014; P