Systolic blood pressure decline in very old individuals is explained by deteriorating health: Longitudinal changes from Umeå85+/GERDA

Declining systolic blood pressure (SBP) is common in very old age and is associated with adverse events, such as dementia. Knowledge of factors associated with SBP changes could explain the etiology of this decline in SBP. This study investigated longitudinal changes in socioeconomic factors, medica...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-12, Vol.96 (51), p.e9161-e9161
Main Authors: Weidung, Bodil, Toots, Annika, Nordström, Peter, Carlberg, Bo, Gustafson, Yngve
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antidepressive Agents - therapeutic use
Blood Pressure
Cardiovascular Diseases - epidemiology
cohort effect
cohort studies
Cross-Sectional Studies
Dementia - epidemiology
Depression - epidemiology
Diabetes Mellitus - epidemiology
Disability Evaluation
Diuretics - therapeutic use
Female
Finland - epidemiology
Health Status
Hip Fractures - epidemiology
Humans
hypertension
hypotension
Longitudinal Studies
Male
Observational Study
Sweden - epidemiology
Systole
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Summary:Declining systolic blood pressure (SBP) is common in very old age and is associated with adverse events, such as dementia. Knowledge of factors associated with SBP changes could explain the etiology of this decline in SBP. This study investigated longitudinal changes in socioeconomic factors, medical conditions, drug prescriptions, and assessments and their associations with SBP changes among very old followed individuals.The study was based on data from the Umeå85+/Gerontological Regional Database (GERDA) cohort study, which provided cross-sectional and longitudinal data on participants aged 85, 90, and ≥95 years from 2000 to 2015. Follow-up assessments were conducted after 5 years. The main outcome was a change in SBP. Factors associated with SBP changes were assessed using multivariate linear regression models.In the Umeå85+/GERDA study, 454 surviving individuals underwent follow-up assessment after 5 years. Of these, 297 had SBP measured at baseline and follow-up. The mean change ± standard deviation in SBP was -12 ± 25 mm Hg. SBP decline was associated independently with later investigation year (P = .009), higher baseline SBP (P 
ISSN:0025-7974
1536-5964
1536-5964
DOI:10.1097/MD.0000000000009161