Reproducibility of heart and thoracic wall position in repeated deep inspiration breath holds for radiotherapy of left-sided breast cancer patients

• Published in: Acta oncologica 2018-10, Vol.57 (10), p.1318-1324
• Main Authors: Wikström, Kenneth, Isacsson, Ulf, Nilsson, Kristina, Ahnesjö, Anders
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Breast Cancer; Breath Holding; Deep Inspiration Breath Hold; Female; Heart - radiation effects; Humans; Middle Aged; Organs at Risk; Radiotherapy; Reproducibility of Results; Retrospective Studies; Thoracic Wall - radiation effects; Tomography, X-Ray Computed; Unilateral Breast Neoplasms - radiotherapy
• ISSN: 0284-186X; 1651-226X; 1651-226X
• DOI: 10.1080/0284186X.2018.1490027

Deep inspiration breath hold (DIBH) for radiotherapy of left-sided breast cancer patients can effectively move the heart away from the target and reduce the heart dose compared to treatments in free breathing. This study aims to investigate the positional reproducibility of heart edge (HE) and thoracic wall (TW) during repeated DIBHs. At three occasions, 11 left-sided breast cancer patients were CT imaged during 6 minutes of repeated DIBHs with 60 cine CT series. The series were evenly distributed over three bed positions and for each bed position, the heart edge associated maximum heart distance (MHD) and thoracic wall-associated maximum lung distance (MLD) from a reference line were retrospectively analyzed. The high temporal resolution of the CT series enabled intrinsic heart movements to be resolved from breath hold variations. A body surface laser scanning system continuously extracted the thorax height and displayed it in a pair of goggles for patient feedback. To check for 'fake-breathing' movements, e.g. that the patient lifts its back from the couch to reach DIBH, the couch-to-spine distance was also measured in all CT series. The analysis was done for 1432 cine CTs captured during 292 breath holds. The DIBH moved the heart on average 15 mm in medial direction compared with free breathing. For the three bed positions studied, the mean value of the max range, across all patients, was between 11-13 mm for the MHD and 4-8 mm for the MLD. The MHD variation due to breath hold variation was twice as large as the MHD variation due to intrinsic heart movement. The couch-to-spine distance varied less than 3 mm for all fractions, i.e., no fake-breathing was discovered. The heart edge and thoracic wall reproducibility was high in relation to the medial heart displacement induced by the DIBH.