Gene therapy clinical trials worldwide to 2017: An update

To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical activity from trial databases, official agency sources, published literature, conference presentations and post...

Full description

Saved in:
Bibliographic Details
Published in:The journal of gene medicine 2018-05, Vol.20 (5), p.e3015-n/a
Main Authors: Ginn, Samantha L., Amaya, Anais K., Alexander, Ian E., Edelstein, Michael, Abedi, Mohammad R.
Format: Article
Language:English
Subjects:
Cancer
Chimeric antigen receptors
Clinical trials
Clinical Trials as Topic - methods
Clinical Trials as Topic - statistics & numerical data
Gene therapy
Genetic Therapy - methods
Genetic Therapy - trends
Genome editing
Genomes
Geographical distribution
Global Health - statistics & numerical data
Global Health - trends
Humans
Immunotherapy, Adoptive - methods
Immunotherapy, Adoptive - trends
Lymphocytes T
Neoplasms - genetics
Neoplasms - therapy
Outcome Assessment, Health Care
The Journal of Gene Medicine
worldwide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical activity from trial databases, official agency sources, published literature, conference presentations and posters kindly provided to us by individual investigators or trial sponsors. This review presents our analysis of clinical trials that, to the best of our knowledge, have been or are being performed worldwide. As of our November 2017 update, we have entries on 2597 trials undertaken in 38 countries. We have analysed the geographical distribution of trials, the disease indications (or other reasons) for trials, the proportions to which different vector types are used, and the genes that have been transferred. Details of the analyses presented, and our searchable database are available via The Journal of Gene Medicine Gene Therapy Clinical Trials Worldwide website at: http://www.wiley.co.uk/genmed/clinical. We also provide an overview of the progress being made in gene therapy clinical trials around the world, and discuss key trends since the previous review, namely the use of chimeric antigen receptor T cells for the treatment of cancer and advancements in genome editing technologies, which have the potential to transform the field moving forward.
ISSN:1099-498X
1521-2254
1521-2254
DOI:10.1002/jgm.3015