The Role of TGF- Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth facto...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-11, Vol.19 (11)
Main Authors: Saito, Akira, Horie, Masafumi, Micke, Patrick, Nagase, Takahide
Format: Article
Language:English
Subjects:
extracellular matrix
idiopathic pulmonary fibrosis
non-small cell lung cancer
Pathology
Patologi
transforming growth factor
tumor microenvironment
usual interstitial pneumonia
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Summary:Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)- signaling plays a central role in tissue fibrosis and tumorigenesis. TGF--mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF- signaling.
ISSN:1661-6596
1422-0067
DOI:10.3390/ijms19113611