Role of conserved local motifs in folding and stability of hGSTP1-1

We investigated, by site directed mutagenesis, the role played by a conserved N-capping box and hydrophobic staple motif in the folding and stability of human GSTPl-1. The corresponding mutants, I149A, S150A, D153A and Y154A, in which these motifs have be

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Bibliographic Details
Published in:Chemico-biological interactions 2001-02, Vol.133 (1-3), p.17
Main Authors: Dragani, B, Stenberg, G, Cocco, R, Mannervik, B, Aceto, A
Format: Article
Language:English
Online Access:Get full text
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Summary:We investigated, by site directed mutagenesis, the role played by a conserved N-capping box and hydrophobic staple motif in the folding and stability of human GSTPl-1. The corresponding mutants, I149A, S150A, D153A and Y154A, in which these motifs have be
ISSN:0009-2797