Maternal smoking early in pregnancy is associated with increased risk of short stature and obesity in adult daughters

We assessed anthropometry in 22,421 adult daughters in association with their mothers’ tobacco smoking early in pregnancy (at their first antenatal visit) in Sweden, particularly their risk of short stature and obesity. Adult daughters were grouped by maternal smoking levels during pregnancy: Non-sm...

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Bibliographic Details
Published in:Scientific reports 2019-03, Vol.9 (1), p.4290-4290, Article 4290
Main Authors: Maessen, Sarah E., Ahlsson, Fredrik, Lundgren, Maria, Cutfield, Wayne S., Derraik, José G. B.
Format: Article
Language:English
Subjects:
692/163/2743/393
692/308/174
Adult Children
Anthropometry
Birth Weight - physiology
Cigarettes
Daughters
Dwarfism - epidemiology
Dwarfism - etiology
Female
Humanities and Social Sciences
Humans
Mothers
multidisciplinary
Nuclear Family
Obesity
Obesity - epidemiology
Obesity - etiology
Offspring
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Science
Science (multidisciplinary)
Smoking
Smoking - adverse effects
Sweden
Tobacco smoking
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Summary:We assessed anthropometry in 22,421 adult daughters in association with their mothers’ tobacco smoking early in pregnancy (at their first antenatal visit) in Sweden, particularly their risk of short stature and obesity. Adult daughters were grouped by maternal smoking levels during pregnancy: Non-smokers (58.5%), Light smokers (24.1%; smoked 1–9 cigarettes/day), and Heavier smokers (17.4%; smoked ≥10 cigarettes/day). Anthropometry was recorded on the adult daughters at approximately 26.0 years of age. Obesity was defined as BMI ≥30 kg/m 2 , and short stature as height more than two standard deviations below the population mean. Daughters whose mothers were Light and Heavier smokers in early pregnancy were 0.8 cm and 1.0 cm shorter, 2.3 kg and 2.6 kg heavier, and had BMI 0.84 kg/m 2 and 1.15 kg/m 2 greater, respectively, than daughters of Non-smokers. The adjusted relative risk of short stature was 55% higher in women born to smokers, irrespectively of smoking levels. Maternal smoking had a dose-dependent association with obesity risk, with offspring of Heavier smokers 61% and of Light smokers 37% more likely to be obese than the daughters of Non-smokers. In conclusion, maternal smoking in pregnancy was associated with an increased risk of short stature and obesity in their adult daughters.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-39006-7