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Purifying Selection in Corvids Is Less Efficient on Islands
Abstract Theory predicts that deleterious mutations accumulate more readily in small populations. As a consequence, mutation load is expected to be elevated in species where life-history strategies and geographic or historical contingencies reduce the number of reproducing individuals. Yet, few stud...
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| Published in: | Molecular biology and evolution 2020-02, Vol.37 (2), p.469-474 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
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| cited_by | cdi_FETCH-LOGICAL-c494t-2269dadc40900a3febdfa8348d804bdffe76b69ad9844f96abbc2fb5c13103b03 |
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| cites | cdi_FETCH-LOGICAL-c494t-2269dadc40900a3febdfa8348d804bdffe76b69ad9844f96abbc2fb5c13103b03 |
| container_end_page | 474 |
| container_issue | 2 |
| container_start_page | 469 |
| container_title | Molecular biology and evolution |
| container_volume | 37 |
| creator | Kutschera, Verena E Poelstra, Jelmer W Botero-Castro, Fidel Dussex, Nicolas Gemmell, Neil J Hunt, Gavin R Ritchie, Michael G Rutz, Christian Wiberg, R Axel W Wolf, Jochen B W |
| description | Abstract
Theory predicts that deleterious mutations accumulate more readily in small populations. As a consequence, mutation load is expected to be elevated in species where life-history strategies and geographic or historical contingencies reduce the number of reproducing individuals. Yet, few studies have empirically tested this prediction using genome-wide data in a comparative framework. We collected whole-genome sequencing data for 147 individuals across seven crow species (Corvus spp.). For each species, we estimated the distribution of fitness effects of deleterious mutations and compared it with proxies of the effective population size Ne. Island species with comparatively smaller geographic range sizes had a significantly increased mutation load. These results support the view that small populations have an elevated risk of mutational meltdown, which may contribute to the higher extinction rates observed in island species. |
| doi_str_mv | 10.1093/molbev/msz233 |
| format | article |
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Theory predicts that deleterious mutations accumulate more readily in small populations. As a consequence, mutation load is expected to be elevated in species where life-history strategies and geographic or historical contingencies reduce the number of reproducing individuals. Yet, few studies have empirically tested this prediction using genome-wide data in a comparative framework. We collected whole-genome sequencing data for 147 individuals across seven crow species (Corvus spp.). For each species, we estimated the distribution of fitness effects of deleterious mutations and compared it with proxies of the effective population size Ne. Island species with comparatively smaller geographic range sizes had a significantly increased mutation load. These results support the view that small populations have an elevated risk of mutational meltdown, which may contribute to the higher extinction rates observed in island species.</description><identifier>ISSN: 0737-4038</identifier><identifier>ISSN: 1537-1719</identifier><identifier>EISSN: 1537-1719</identifier><identifier>DOI: 10.1093/molbev/msz233</identifier><identifier>PMID: 31633794</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>avian genomics ; comparative analysis ; Discoveries ; distribution of fitness effects ; molecular evolution ; mutation load ; selection</subject><ispartof>Molecular biology and evolution, 2020-02, Vol.37 (2), p.469-474</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-2269dadc40900a3febdfa8348d804bdffe76b69ad9844f96abbc2fb5c13103b03</citedby><cites>FETCH-LOGICAL-c494t-2269dadc40900a3febdfa8348d804bdffe76b69ad9844f96abbc2fb5c13103b03</cites><orcidid>0000-0002-8930-534X ; 0000-0002-2958-5183 ; 0000-0002-5062-8272</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993847/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993847/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1598,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31633794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-180446$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408110$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kutschera, Verena E</creatorcontrib><creatorcontrib>Poelstra, Jelmer W</creatorcontrib><creatorcontrib>Botero-Castro, Fidel</creatorcontrib><creatorcontrib>Dussex, Nicolas</creatorcontrib><creatorcontrib>Gemmell, Neil J</creatorcontrib><creatorcontrib>Hunt, Gavin R</creatorcontrib><creatorcontrib>Ritchie, Michael G</creatorcontrib><creatorcontrib>Rutz, Christian</creatorcontrib><creatorcontrib>Wiberg, R Axel W</creatorcontrib><creatorcontrib>Wolf, Jochen B W</creatorcontrib><title>Purifying Selection in Corvids Is Less Efficient on Islands</title><title>Molecular biology and evolution</title><addtitle>Mol Biol Evol</addtitle><description>Abstract
Theory predicts that deleterious mutations accumulate more readily in small populations. As a consequence, mutation load is expected to be elevated in species where life-history strategies and geographic or historical contingencies reduce the number of reproducing individuals. Yet, few studies have empirically tested this prediction using genome-wide data in a comparative framework. We collected whole-genome sequencing data for 147 individuals across seven crow species (Corvus spp.). For each species, we estimated the distribution of fitness effects of deleterious mutations and compared it with proxies of the effective population size Ne. Island species with comparatively smaller geographic range sizes had a significantly increased mutation load. These results support the view that small populations have an elevated risk of mutational meltdown, which may contribute to the higher extinction rates observed in island species.</description><subject>avian genomics</subject><subject>comparative analysis</subject><subject>Discoveries</subject><subject>distribution of fitness effects</subject><subject>molecular evolution</subject><subject>mutation load</subject><subject>selection</subject><issn>0737-4038</issn><issn>1537-1719</issn><issn>1537-1719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqNkc1P3DAQxS1UBAvtkWuVYw8E7IxxYlWqhJaPrrQSSP24Wo5jL66SeOvZLIK_HqNsFziV04w0v3lv7EfIEaMnjEo47UJb2_Vph48FwA6ZsDMoc1Yy-YFMaJl6TqHaJweIfyhlnAuxR_aBCYBS8gn5ejtE7x58v8h-2NaalQ995vtsGuLaN5jNMJtbxOzSOW-87VdZms-w1X2DH8mu0y3aT5t6SH5dXf6cfs_nN9ez6fk8N1zyVV4UQja6MZxKSjU4WzdOV8CrpqI89c6WohZSN7Li3Emh69oUrj4zDBiFmsIhOR518d4uh1oto-90fFBBe3Xhf5-rEBdqGBSnFWPvxHFQLNlzkfBvI57YzjYmvTHq9s3W20nv79QirJWQEipeJoEvG4EY_g4WV6rzaGyb_siGAVUBKQcJwIuE5iNqYkCM1m1tGFXPcaoxTjXGmfjPr2_b0v_ye_EOw_I_Wk96i60L</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Kutschera, Verena E</creator><creator>Poelstra, Jelmer W</creator><creator>Botero-Castro, Fidel</creator><creator>Dussex, Nicolas</creator><creator>Gemmell, Neil J</creator><creator>Hunt, Gavin R</creator><creator>Ritchie, Michael G</creator><creator>Rutz, Christian</creator><creator>Wiberg, R Axel W</creator><creator>Wolf, Jochen B W</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ABAVF</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG7</scope><scope>ZZAVC</scope><scope>ACNBI</scope><scope>DF2</scope><orcidid>https://orcid.org/0000-0002-8930-534X</orcidid><orcidid>https://orcid.org/0000-0002-2958-5183</orcidid><orcidid>https://orcid.org/0000-0002-5062-8272</orcidid></search><sort><creationdate>20200201</creationdate><title>Purifying Selection in Corvids Is Less Efficient on Islands</title><author>Kutschera, Verena E ; Poelstra, Jelmer W ; Botero-Castro, Fidel ; Dussex, Nicolas ; Gemmell, Neil J ; Hunt, Gavin R ; Ritchie, Michael G ; Rutz, Christian ; Wiberg, R Axel W ; Wolf, Jochen B W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-2269dadc40900a3febdfa8348d804bdffe76b69ad9844f96abbc2fb5c13103b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>avian genomics</topic><topic>comparative analysis</topic><topic>Discoveries</topic><topic>distribution of fitness effects</topic><topic>molecular evolution</topic><topic>mutation load</topic><topic>selection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kutschera, Verena E</creatorcontrib><creatorcontrib>Poelstra, Jelmer W</creatorcontrib><creatorcontrib>Botero-Castro, Fidel</creatorcontrib><creatorcontrib>Dussex, Nicolas</creatorcontrib><creatorcontrib>Gemmell, Neil J</creatorcontrib><creatorcontrib>Hunt, Gavin R</creatorcontrib><creatorcontrib>Ritchie, Michael G</creatorcontrib><creatorcontrib>Rutz, Christian</creatorcontrib><creatorcontrib>Wiberg, R Axel W</creatorcontrib><creatorcontrib>Wolf, Jochen B W</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Stockholms universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Stockholms universitet</collection><collection>SwePub Articles full text</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Molecular biology and evolution</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kutschera, Verena E</au><au>Poelstra, Jelmer W</au><au>Botero-Castro, Fidel</au><au>Dussex, Nicolas</au><au>Gemmell, Neil J</au><au>Hunt, Gavin R</au><au>Ritchie, Michael G</au><au>Rutz, Christian</au><au>Wiberg, R Axel W</au><au>Wolf, Jochen B W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Purifying Selection in Corvids Is Less Efficient on Islands</atitle><jtitle>Molecular biology and evolution</jtitle><addtitle>Mol Biol Evol</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>37</volume><issue>2</issue><spage>469</spage><epage>474</epage><pages>469-474</pages><issn>0737-4038</issn><issn>1537-1719</issn><eissn>1537-1719</eissn><abstract>Abstract
Theory predicts that deleterious mutations accumulate more readily in small populations. As a consequence, mutation load is expected to be elevated in species where life-history strategies and geographic or historical contingencies reduce the number of reproducing individuals. Yet, few studies have empirically tested this prediction using genome-wide data in a comparative framework. We collected whole-genome sequencing data for 147 individuals across seven crow species (Corvus spp.). For each species, we estimated the distribution of fitness effects of deleterious mutations and compared it with proxies of the effective population size Ne. Island species with comparatively smaller geographic range sizes had a significantly increased mutation load. These results support the view that small populations have an elevated risk of mutational meltdown, which may contribute to the higher extinction rates observed in island species.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>31633794</pmid><doi>10.1093/molbev/msz233</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8930-534X</orcidid><orcidid>https://orcid.org/0000-0002-2958-5183</orcidid><orcidid>https://orcid.org/0000-0002-5062-8272</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | avian genomics comparative analysis Discoveries distribution of fitness effects molecular evolution mutation load selection |
| title | Purifying Selection in Corvids Is Less Efficient on Islands |
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