Affibody Molecules as Targeting Vectors for PET Imaging

Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be selected to bind to a large variety of proteins with a high affinity. Their small size and high affinity make them attractive as targeting vectors for molecular imaging. High-affinity affibody binders have been se...

Full description

Saved in:
Bibliographic Details
Published in:Cancers 2020-03, Vol.12 (3), p.651
Main Authors: Tolmachev, Vladimir, Orlova, Anna
Format: Article
Language:English
Subjects:
affibody molecules
Affinity
Amino acids
Breast cancer
EGFR
Epidermal growth factor
ErbB-2 protein
HER2
Immunoglobulins
Labeling
Localization
Metastases
molecular imaging
Peptides
Permits
PET
Prostheses
Proteins
radiolabeling
Review
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be selected to bind to a large variety of proteins with a high affinity. Their small size and high affinity make them attractive as targeting vectors for molecular imaging. High-affinity affibody binders have been selected for several cancer-associated molecular targets. Preclinical studies have shown that radiolabeled affibody molecules can provide highly specific and sensitive imaging on the day of injection; however, for a few targets, imaging on the next day further increased the imaging sensitivity. A phase I/II clinical trial showed that Ga-labeled affibody molecules permit an accurate and specific measurement of HER2 expression in breast cancer metastases. This paper provides an overview of the factors influencing the biodistribution and targeting properties of affibody molecules and the chemistry of their labeling using positron emitters.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12030651