Extracellular vesicles in atrial fibrillation and stroke

Atrial fibrillation (AF) is associated with a 5-fold increased risk of thromboembolic stroke. Extracellular vesicles (EVs) convey pathophysiological information and are possible biomarkers for risk of stroke. EVs were measured in 836 patients with AF (of which 280 were stroke cases) selected from th...

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Bibliographic Details
Published in:Thrombosis research 2020-09, Vol.193, p.180-189
Main Authors: Thulin, Åsa, Lindbäck, Johan, Granger, Christopher B., Wallentin, Lars, Lind, Lars, Siegbahn, Agneta
Format: Article
Language:English
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Summary:Atrial fibrillation (AF) is associated with a 5-fold increased risk of thromboembolic stroke. Extracellular vesicles (EVs) convey pathophysiological information and are possible biomarkers for risk of stroke. EVs were measured in 836 patients with AF (of which 280 were stroke cases) selected from the ARISTOTLE trial and in a cohort of unselected 70 year old individuals (n = 1007, reference material). EVs from platelets, leukocytes, erythrocytes and inflammatory endothelial cells were measured using flow cytometry and a solid-phase proximity ligation assay. Concentrations of EVs were higher in the ARISTOTLE patients than in the PIVUS cohort for all the EV groups except EVs from endothelial cells (p 
ISSN:0049-3848
1879-2472
1879-2472
DOI:10.1016/j.thromres.2020.07.029