3D-printing of solid lipid tablets from emulsion gels

[Display omitted] Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms is driven by the need for personalized medicines. Most research to date has focused on printing of polymeric-based drug delivery systems at high temperatures. Furthermore, oral formulation de...

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Bibliographic Details
Published in:International journal of pharmaceutics 2021-03, Vol.597, p.120304-120304, Article 120304
Main Authors: Johannesson, Jenny, Khan, Jamal, Hubert, Madlen, Teleki, Alexandra, Bergström, Christel A.S.
Format: Article
Language:English
Subjects:
3D-printing
Emulsion gel
Lipid-based formulation
Poorly water-soluble drug
Semi-solid extrusion
Solid lipid tablet
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Summary:[Display omitted] Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms is driven by the need for personalized medicines. Most research to date has focused on printing of polymeric-based drug delivery systems at high temperatures. Furthermore, oral formulation development is continuously challenged by the large number of poorly water-soluble drugs, which require more advanced enabling formulations to improve oral bioavailability. In this work, we used semi-solid extrusion (SSE) printing of emulsion gels with three types of emulsified lipid-based formulations (LBFs) to produce solid lipid tablets incorporating the poorly water-soluble drug, fenofibrate. Tablets were successfully 3D-printed from emulsion gels using SSE at room temperature, making the methodology particularly useful for thermolabile compounds. The tablets were well-defined in mass and disintegrated rapidly (
ISSN:0378-5173
1873-3476
1873-3476
DOI:10.1016/j.ijpharm.2021.120304