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Biocompatible biogenic silver nanoparticles interact with caspases on an atomic level to elicit apoptosis
To synthesize biocompatible and ecofriendly silver nanoparticles (AgNPs) and elucidate their molecular and cellular nanotoxicity at an atomic level. AgNPs were biosynthesized using Andrographolide and their cellular and molecular biocompatibility was evaluated using zebrafish embryos. AgNPs with a s...
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| Published in: | Nanomedicine (London, England) England), 2020-09, Vol.15 (22), p.2119-2132 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c352t-661e731c057a0ee5bfbbc69dc97039be069d60a3306cb9fd6e3152af4690a283 |
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| cites | cdi_FETCH-LOGICAL-c352t-661e731c057a0ee5bfbbc69dc97039be069d60a3306cb9fd6e3152af4690a283 |
| container_end_page | 2132 |
| container_issue | 22 |
| container_start_page | 2119 |
| container_title | Nanomedicine (London, England) |
| container_volume | 15 |
| creator | Kumari, Shalini Kumari, Puja Panda, Pritam K Patel, Paritosh Jha, Ealisha Mallick, M Anwar &, Mrutyunjay Suar Verma, Suresh K |
| description | To synthesize biocompatible and ecofriendly silver nanoparticles (AgNPs) and elucidate their
molecular and cellular nanotoxicity at an atomic level.
AgNPs were biosynthesized using Andrographolide and their
cellular and molecular biocompatibility was evaluated using zebrafish embryos.
AgNPs with a size of 80 nm and ζ potential of -52 mV were obtained. The LC50 for the AgNPs embryonic zebrafish was found to be 125 μg/ml. AgNPs induced reactive oxygen species production and elicit apoptosis mechanistically, then nanoparticles were shown to interact with caspase-3 and caspase-9 proteins through proline, cysteine, glycine and histidine amino acid residues via H-bond of corresponding bond energies.
Biosynthesized AgNPs have potential to be used for biomedical and therapeutic applications. |
| doi_str_mv | 10.2217/nnm-2020-0138 |
| format | article |
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molecular and cellular nanotoxicity at an atomic level.
AgNPs were biosynthesized using Andrographolide and their
cellular and molecular biocompatibility was evaluated using zebrafish embryos.
AgNPs with a size of 80 nm and ζ potential of -52 mV were obtained. The LC50 for the AgNPs embryonic zebrafish was found to be 125 μg/ml. AgNPs induced reactive oxygen species production and elicit apoptosis mechanistically, then nanoparticles were shown to interact with caspase-3 and caspase-9 proteins through proline, cysteine, glycine and histidine amino acid residues via H-bond of corresponding bond energies.
Biosynthesized AgNPs have potential to be used for biomedical and therapeutic applications.</description><identifier>ISSN: 1743-5889</identifier><identifier>ISSN: 1748-6963</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2020-0138</identifier><language>eng</language><publisher>London: Future Medicine Ltd</publisher><subject>Andrographis paniculata ; Apoptosis ; Biocompatibility ; biological synthesis ; caspase ; Cytotoxicity ; Eggs ; Metabolism ; Nanomaterials ; Nanoparticles ; Reactive oxygen species ; ROS ; Silver ; silver nanoparticles ; Spectrum analysis ; Zebrafish</subject><ispartof>Nanomedicine (London, England), 2020-09, Vol.15 (22), p.2119-2132</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Sep 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-661e731c057a0ee5bfbbc69dc97039be069d60a3306cb9fd6e3152af4690a283</citedby><cites>FETCH-LOGICAL-c352t-661e731c057a0ee5bfbbc69dc97039be069d60a3306cb9fd6e3152af4690a283</cites><orcidid>0000-0003-1029-9766</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-439170$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumari, Shalini</creatorcontrib><creatorcontrib>Kumari, Puja</creatorcontrib><creatorcontrib>Panda, Pritam K</creatorcontrib><creatorcontrib>Patel, Paritosh</creatorcontrib><creatorcontrib>Jha, Ealisha</creatorcontrib><creatorcontrib>Mallick, M Anwar</creatorcontrib><creatorcontrib>&, Mrutyunjay Suar</creatorcontrib><creatorcontrib>Verma, Suresh K</creatorcontrib><title>Biocompatible biogenic silver nanoparticles interact with caspases on an atomic level to elicit apoptosis</title><title>Nanomedicine (London, England)</title><description>To synthesize biocompatible and ecofriendly silver nanoparticles (AgNPs) and elucidate their
molecular and cellular nanotoxicity at an atomic level.
AgNPs were biosynthesized using Andrographolide and their
cellular and molecular biocompatibility was evaluated using zebrafish embryos.
AgNPs with a size of 80 nm and ζ potential of -52 mV were obtained. The LC50 for the AgNPs embryonic zebrafish was found to be 125 μg/ml. AgNPs induced reactive oxygen species production and elicit apoptosis mechanistically, then nanoparticles were shown to interact with caspase-3 and caspase-9 proteins through proline, cysteine, glycine and histidine amino acid residues via H-bond of corresponding bond energies.
Biosynthesized AgNPs have potential to be used for biomedical and therapeutic applications.</description><subject>Andrographis paniculata</subject><subject>Apoptosis</subject><subject>Biocompatibility</subject><subject>biological synthesis</subject><subject>caspase</subject><subject>Cytotoxicity</subject><subject>Eggs</subject><subject>Metabolism</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Reactive oxygen species</subject><subject>ROS</subject><subject>Silver</subject><subject>silver nanoparticles</subject><subject>Spectrum analysis</subject><subject>Zebrafish</subject><issn>1743-5889</issn><issn>1748-6963</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LxDAQhoMoqKtH7wGvVvPRps1R108QvIjXkGana5Y2qUm64r83a8WbMDCT8MzL8CB0RsklY7S-cm4oGGGkIJQ3e-iI1mVTCCn4_s_Mi6pp5CE6jnFDSNUwSo6QvbHe-GHUybY94Nb6NThrcLT9FgJ22vlRh2RNDxFblyBok_CnTe_Y6DjqmL-9wzpX8kNe7GELPU4eQ2-NTViPfkw-2niCDjrdRzj97Qv0en_3unwsnl8enpbXz4XhFUuFEBRqTg2pak0AqrZrWyPkysiacNkCybMgmnMiTCu7lQBOK6a7UkiiWcMX6GKOjZ8wTq0agx10-FJeW3Vr366VD2s1TarkkubEBTqf8TH4jwliUhs_BZcPVKxs6rIqS0kzVcyUCT7GAN1fLCVq515l92rnXu3cZ17OfDelKUA0FpwBNb8GWGUzDv7Z_QZmVo0O</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Kumari, Shalini</creator><creator>Kumari, Puja</creator><creator>Panda, Pritam K</creator><creator>Patel, Paritosh</creator><creator>Jha, Ealisha</creator><creator>Mallick, M Anwar</creator><creator>&, Mrutyunjay Suar</creator><creator>Verma, Suresh K</creator><general>Future Medicine Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><orcidid>https://orcid.org/0000-0003-1029-9766</orcidid></search><sort><creationdate>20200901</creationdate><title>Biocompatible biogenic silver nanoparticles interact with caspases on an atomic level to elicit apoptosis</title><author>Kumari, Shalini ; 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molecular and cellular nanotoxicity at an atomic level.
AgNPs were biosynthesized using Andrographolide and their
cellular and molecular biocompatibility was evaluated using zebrafish embryos.
AgNPs with a size of 80 nm and ζ potential of -52 mV were obtained. The LC50 for the AgNPs embryonic zebrafish was found to be 125 μg/ml. AgNPs induced reactive oxygen species production and elicit apoptosis mechanistically, then nanoparticles were shown to interact with caspase-3 and caspase-9 proteins through proline, cysteine, glycine and histidine amino acid residues via H-bond of corresponding bond energies.
Biosynthesized AgNPs have potential to be used for biomedical and therapeutic applications.</abstract><cop>London</cop><pub>Future Medicine Ltd</pub><doi>10.2217/nnm-2020-0138</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-1029-9766</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1743-5889 |
| ispartof | Nanomedicine (London, England), 2020-09, Vol.15 (22), p.2119-2132 |
| issn | 1743-5889 1748-6963 1748-6963 |
| language | eng |
| recordid | cdi_swepub_primary_oai_DiVA_org_uu_439170 |
| source | PubMed (Medline) |
| subjects | Andrographis paniculata Apoptosis Biocompatibility biological synthesis caspase Cytotoxicity Eggs Metabolism Nanomaterials Nanoparticles Reactive oxygen species ROS Silver silver nanoparticles Spectrum analysis Zebrafish |
| title | Biocompatible biogenic silver nanoparticles interact with caspases on an atomic level to elicit apoptosis |
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