Unboxing mutations: Connecting mutation types with evolutionary consequences

A key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types (e.g., SNPs, translocations and inversions). To do this we must simultaneously consider different mutation types in an evolutionary framewo...

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Bibliographic Details
Published in:Molecular ecology 2021-06, Vol.30 (12), p.2710-2723
Main Authors: Berdan, Emma L., Blanckaert, Alexandre, Slotte, Tanja, Suh, Alexander, Westram, Anja M., Fragata, Inês
Format: Article
Language:English
Subjects:
adaptation
Adaptation, Physiological
Biological Evolution
Chromosome Inversion
distribution of fitness effects
Evolution
Genetic effects
Genetics, Population
Inversions
Models, Genetic
Mutation
Mutation Rate
Population Density
Population genetics
recombination
Selection, Genetic
Single-nucleotide polymorphism
speciation
structural variant
Translocation
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Summary:A key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types (e.g., SNPs, translocations and inversions). To do this we must simultaneously consider different mutation types in an evolutionary framework. Here, we propose a research framework that directly utilizes the most important characteristics of mutations, their population genetic effects, to determine their relative evolutionary significance in a given scenario. We review known population genetic effects of different mutation types and show how these may be connected to different evolutionary outcomes. We provide examples of how to implement this framework and pinpoint areas where more data, theory and synthesis are needed. Linking experimental and theoretical approaches to examine different mutation types simultaneously is a critical step towards understanding their evolutionary significance.
ISSN:0962-1083
1365-294X
1365-294X
DOI:10.1111/mec.15936