Mixed hepatocellular and cholangiocarcinoma: a rare tumor with a mix of parent phenotypic characteristics

Abstract Background Intrahepatic lesions of mixed hepatocellular (HCC) and intrahepatic cholangiocellular carcinoma (ICC) histology are rare. The aim was to describe the natural history of these tumors relative to monomorphic ICC or HCC utilizing the National Cancer Data Base (NCDB). Methods Patient...

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Bibliographic Details
Published in:HPB (Oxford, England) England), 2016-11, Vol.18 (11), p.886-892
Main Authors: Bergquist, John R, Groeschl, Ryan T, Ivanics, Tommy, Shubert, Christopher R, Habermann, Elizabeth B, Kendrick, Michael L, Farnell, Michael B, Nagorney, David M, Truty, Mark J, Smoot, Rory L
Format: Article
Language:English
Subjects:
Bile Duct Neoplasms - mortality
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Chi-Square Distribution
Cholangiocarcinoma - mortality
Cholangiocarcinoma - pathology
Cholangiocarcinoma - surgery
Databases, Factual
Female
Gastroenterology
Gastroenterology and Hepatology
Hepatectomy
Hepatology
Humans
Kaplan-Meier Estimate
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Neoplasms, Complex and Mixed - mortality
Neoplasms, Complex and Mixed - pathology
Neoplasms, Complex and Mixed - surgery
Original
Phenotype
Proportional Hazards Models
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
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Summary:Abstract Background Intrahepatic lesions of mixed hepatocellular (HCC) and intrahepatic cholangiocellular carcinoma (ICC) histology are rare. The aim was to describe the natural history of these tumors relative to monomorphic ICC or HCC utilizing the National Cancer Data Base (NCDB). Methods Patients with ICC, HCC, and mixed histology (cHCC-CCA) were identified in the NCDB (2004–2012). Inter-group comparisons were made. Kaplan–Meier and multivariable Cox Proportional Hazards analyzed overall survival. Results The query identified 90,499 patients with HCC; 14,463 with ICC; and 1141 with cHCC-CCA histology. Patients with cHCC-CCA histology were relatively young (61 vs. 62 (HCC, p = 0.877) and 67 (ICC, p 
ISSN:1365-182X
1477-2574
1477-2574
DOI:10.1016/j.hpb.2016.07.006