Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review

•Stress reactivity is potentiated in LNG-IUD users compared to control women.•Inconsistent data on the effect of LNG-IUD on mental health.•Quality of life improves under LNG-IUD use.•Improvement of sexual functioning in LNG-IUD users compared to control women.•No difference in sexual function betwee...

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Bibliographic Details
Published in:Frontiers in neuroendocrinology 2021-10, Vol.63, p.100943-100943, Article 100943
Main Authors: Bürger, Zoé, Bucher, Anna Magdalena, Comasco, Erika, Henes, Melanie, Hübner, Stephanie, Kogler, Lydia, Derntl, Birgit
Format: Article
Language:English
Subjects:
Depression
Female
Hormonal contraception
Humans
Intrauterine Devices, Medicated
Levonorgestrel - adverse effects
Levonorgestrel intrauterine device
LNG-IUD
Mental Health
Progestin
Quality of Life
Sexual functioning
Stress reactivity
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Summary:•Stress reactivity is potentiated in LNG-IUD users compared to control women.•Inconsistent data on the effect of LNG-IUD on mental health.•Quality of life improves under LNG-IUD use.•Improvement of sexual functioning in LNG-IUD users compared to control women.•No difference in sexual function between LNG-IUD and copper-IUD users. Levonorgestrel-intrauterine-devices (LNG-IUD) are one of the most used contraceptive methods worldwide. While several reviews exist on how LNG-IUDs impact physiology and gynaecological functions, this systematic review focuses on stress, mental health, quality of life, sexual functioning, and effects on brain architecture. While data on stress is scarce, results on mental health are ambiguous. More consistently, LNG-IUD use seems to improve quality of life and sexual functioning. No studies highlighting the consequences of LNG-IUD use on the brain were found. The reviewed studies are characterized by a substantial variation in approaches, participant groups, and study quality. More high-quality research assessing the effects of LNG-IUD on mental health, including response to stressors and brain function and structure, is needed to identify women vulnerable to adverse effects of LNG-IUD, also in comparison to oral contraceptives, and to empower women to make more informed choices concerning hormonal contraception.
ISSN:0091-3022
1095-6808
1095-6808
DOI:10.1016/j.yfrne.2021.100943