Targeting LIN28: a new hope in prostate cancer theranostics

The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2021-10, Vol.17 (29), p.3873-3880
Main Authors: Shrivastava, Garima, Aljabali, Alaa Aa, Shahcheraghi, Seyed Hossein, Lotfi, Marzieh, Shastri, Madhur D, Shukla, Shakti D, Chellappan, Dinesh K, Jha, Niraj Kumar, Anand, Krishnan, Dureja, Harish, Pabari, Ritesh M, Mishra, Vijay, Almutary, Abdulmajeed G, Alnuqaydan, Abdullah M, Charbe, Nitin, Prasher, Parteek, Negi, Poonam, Goyal, Rohit, Dua, Kamal, Gupta, Gaurav, Serrano-Aroca, Ángel, Bahar, Bojlul, Barh, Debmalya, Panda, Pritam Kumar, Takayama, Kazuo, Lundstorm, Kenneth, McCarron, Paul, Bakshi, Hamid, Tambuwala, Murtaza M
Format: Article
Language:English
Subjects:
biomarker
Humans
LIN28A
LIN28B
Male
Molecular Targeted Therapy
Precision Medicine
prostate cancer
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
RNA-Binding Proteins - metabolism
theranostic
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Summary:The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area.
ISSN:1479-6694
1744-8301
1744-8301
DOI:10.2217/fon-2021-0247