Cognitive Reserve, Early Cognitive Screening, and Relationship to Long-Term Outcome after Severe Traumatic Brain Injury

The objective was to investigate the relationship between early global cognitive functioning using the Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS) and cognitive flexibility (Trail Making Test (TMT), TMT B-A), with long-term outcome assessed by the Mayo-Portland Adaptabi...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-04, Vol.11 (7), p.2046
Main Authors: Ekdahl, Natascha, Godbolt, Alison K, Deboussard, Catharina Nygren, Lannsjö, Marianne, Stålnacke, Britt-Marie, Stenberg, Maud, Ulfarsson, Trandur, Möller, Marika C
Format: Article
Language:English
Subjects:
Adjustment
Age
Clinical medicine
cognition
Cognitive ability
education
Executive function
Intensive care
Investigations
Neuropsychology
patient outcome assessment
prognosis
Rehabilitation
Social research
Traumatic brain injury
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Summary:The objective was to investigate the relationship between early global cognitive functioning using the Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS) and cognitive flexibility (Trail Making Test (TMT), TMT B-A), with long-term outcome assessed by the Mayo-Portland Adaptability Index (MPAI-4) in severe traumatic brain injury (sTBI) controlling for the influence of cognitive reserve, age, and injury severity. Of 114 patients aged 18-65 with acute Glasgow Coma Scale 3-8, 41 patients were able to complete (BNIS) at 3 months after injury and MPAI-4 5-8 years after injury. Of these, 33 patients also completed TMT at 3 months. Global cognition and cognitive flexibility correlated significantly with long-term outcome measured with MPAI-4 total score (r = 0.315; r = 0.355). Global cognition correlated significantly with the participation subscale (r = 0.388), while cognitive flexibility correlated with the adjustment (r = 0.364) and ability (r = 0.364) subscales. Adjusting for cognitive reserve and acute injury severity did not alter these relationships. The effect size for education on BNIS and TMT scores was large (d ≈ 0.85). Early screenings with BNIS and TMT are related to long-term outcome after sTBI and seem to measure complementary aspects of outcome. As early as 3 months after sTBI, educational level influences the scores on neuropsychological screening instruments.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11072046