Tackling the cytokine storm using advanced drug delivery in allergic airway disease

Asthma is one of the leading causes of mortality worldwide presenting a huge socio-economic burden with rising morbidity and mortality rates. It is a chronic inflammatory airway disease that is eminent with multiple epidemiological and pathophysiological features such as over production of pro-infla...

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Published in:Journal of drug delivery science and technology 2023-04, Vol.82, p.104366, Article 104366
Main Authors: Patel, Vyoma K., Vishwas, Sukriti, Kumar, Rajan, De Rubis, Gabriele, Shukla, Shakti D., Paudel, Keshav Raj, Manandhar, Bikash, Singh, Thakur Gurjeet, Chellappan, Dinesh Kumar, Gulati, Monica, Kaur, Indu Pal, Allam, Venkata Sita Rama Raju, Hansbro, Philip M., Oliver, Brian G., MacLoughlin, Ronan, Singh, Sachin Kumar, Dua, Kamal
Format: Article
Language:English
Subjects:
Asthma
Clinical trials
Cytokines
Drug delivery systems
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Summary:Asthma is one of the leading causes of mortality worldwide presenting a huge socio-economic burden with rising morbidity and mortality rates. It is a chronic inflammatory airway disease that is eminent with multiple epidemiological and pathophysiological features such as over production of pro-inflammatory cytokines that triggers an uncontrolled aberrant inflammatory response known as ‘cytokine storm’. This phenomenon interferes with the signalling and production of cytokines over time leading to the progression of disease and the development of complications that lead to fatal consequences in many individuals. Targeting this overproduction and signalling of cytokines may prove a promising approach to develop novel cytokine specific therapies in the treatment of asthma. This review discusses on the various pharmacological strategies, recent advancements in drug delivery systems and significant findings from clinical trials that may have a potential to outweigh the limitations of the current therapies in the treatment of asthma. [Display omitted] •Cytokine storm is one of the key epidemiological and pathophysiological features of asthma.•Targeting cytokine storm may serve as a promising approach to develop novel cytokine specific therapies in treatment of asthma.•The ongoing developments in gene therapy, drug delivery systems and clinical trials may unravel the complexity of asthma.
ISSN:1773-2247
DOI:10.1016/j.jddst.2023.104366