Insights into mammalian TE diversity through the curation of 248 genome assemblies

We examined transposable element (TE) content of 248 placental mammal genome assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that although mammals resemble one another in total TE content and diversity, they show substantial differences with regard to recent TE acc...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2023-04, Vol.380 (6643), p.eabn1430-eabn1430
Main Authors: Osmanski, Austin B, Paulat, Nicole S, Korstian, Jenny, Grimshaw, Jenna R, Halsey, Michaela, Sullivan, Kevin A M, Moreno-Santillán, Diana D, Crookshanks, Claudia, Roberts, Jacquelyn, Garcia, Carlos, Johnson, Matthew G, Densmore, Llewellyn D, Stevens, Richard D, Rosen, Jeb, Storer, Jessica M, Hubley, Robert, Smit, Arian F A, Dávalos, Liliana M, Karlsson, Elinor K, Lindblad-Toh, Kerstin, Ray, David A
Format: Article
Language:English
Subjects:
Accumulation
Animals
Annotations
Assemblies
Bats
Biological evolution
Comparative analysis
Consortia
Datasets
Datasets as Topic
Deoxyribonucleic acid
DNA
DNA Transposable Elements
Eutheria
Eutheria - genetics
Evolution
Evolution, Molecular
Feeding Behavior
Female
Gene regulation
Genetic Variation
Genomes
Genomics
Inversions
Long Interspersed Nucleotide Elements
Mammals
Pregnancy
Taxonomy
Translocation
Transposons
Variation
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Summary:We examined transposable element (TE) content of 248 placental mammal genome assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that although mammals resemble one another in total TE content and diversity, they show substantial differences with regard to recent TE accumulation. This includes multiple recent expansion and quiescence events across the mammalian tree. Young TEs, particularly long interspersed elements, drive increases in genome size, whereas DNA transposons are associated with smaller genomes. Mammals tend to accumulate only a few types of TEs at any given time, with one TE type dominating. We also found association between dietary habit and the presence of DNA transposon invasions. These detailed annotations will serve as a benchmark for future comparative TE analyses among placental mammals.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.abn1430