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Low-molecular weight sulfated marine polysaccharides: Promising molecules to prevent neurodegeneration in mucopolysaccharidosis IIIA?

Mucopolysaccharidosis IIIA is a hereditary disease caused by mutations in the sulfamidase enzyme that participates in catabolism of heparan sulfate (HS), leading to HS fragment accumulation and multisystemic failure. No cure exists and death occurs around the second decade of life. Two low molecular...

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Published in:Carbohydrate polymers 2023-11, Vol.320, p.121214-121214, Article 121214
Main Authors: Veraldi, Noemi, Quadri, Isabelle Dentand, van de Looij, Yohan, Modernell, Laura Malaguti, Sinquin, Corinne, Zykwinska, Agata, Tournier, Benjamin B., Dalonneau, Fabien, Li, Honglian, Li, Jin-Ping, Millet, Philippe, Vives, Romain, Colliec-Jouault, Sylvia, de Agostini, Ariane, Sanches, Eduardo Farias, Sizonenko, Stéphane V.
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creator Veraldi, Noemi
Quadri, Isabelle Dentand
van de Looij, Yohan
Modernell, Laura Malaguti
Sinquin, Corinne
Zykwinska, Agata
Tournier, Benjamin B.
Dalonneau, Fabien
Li, Honglian
Li, Jin-Ping
Millet, Philippe
Vives, Romain
Colliec-Jouault, Sylvia
de Agostini, Ariane
Sanches, Eduardo Farias
Sizonenko, Stéphane V.
description Mucopolysaccharidosis IIIA is a hereditary disease caused by mutations in the sulfamidase enzyme that participates in catabolism of heparan sulfate (HS), leading to HS fragment accumulation and multisystemic failure. No cure exists and death occurs around the second decade of life. Two low molecular weight highly sulfated compounds derived from marine diabolican and infernan exopolysaccharides (A5_3 and A5_4, respectively) with heparanase inhibiting properties were tested in a MPSIIIA cell line model, resulting in limited degradation of intracellular HS. Next, we observed the effects of intraperitoneal injections of the diabolican derivative A5_3 from 4 to 12 weeks of age on MPSIIIA mice. Brain metabolism and microstructure, levels of proteins and genes involved in MPSIIIA brain pathophysiology were also investigated. 1H-Magnetic Resonance Spectroscopy (MRS) indicated deficits in energetic metabolism, tissue integrity and neurotransmission at both 4 and 12 weeks in MPSIIIA mice, with partial protective effects of A5_3. Ex-vivo Diffusion Tensor Imaging (DTI) showed white matter microstructural damage in MPSIIIA, with noticeable protective effects of A5_3. Protein and gene expression assessments displayed both pro-inflammatory and pro-apoptotic profiles in MPSIIIA mice, with benefits of A5_3 counteracting neuroinflammation. Overall, derivative A5_3 was well tolerated and was shown to be efficient in preventing brain metabolism failure and inflammation, resulting in preserved brain microstructure in the context of MPSIIIA. [Display omitted]
doi_str_mv 10.1016/j.carbpol.2023.121214
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source ScienceDirect Journals
subjects Chemical Sciences
Heparan sulfate
Life Sciences
Magnetic spectroscopy resonance
Marine polysaccharides
Medicinal Chemistry
Mucopolysaccharidosis
Neurobiology
Neurons and Cognition
title Low-molecular weight sulfated marine polysaccharides: Promising molecules to prevent neurodegeneration in mucopolysaccharidosis IIIA?
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