Fmoc protected peptide mimetic based on a cyclohexane framework and incorporation into angiotensin II

1,3,5-syn substituted cyclohexane based amino acids have been prepared and incorporated into synthetic peptides to serve as scaffold mimicking the Val-Tyr-Ile sequence of angiotensin II. The conformationally constrained tripeptide mimetic holds potential use as a γ-turn replacement. Cyclohexane base...

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Bibliographic Details
Published in:Tetrahedron 1997-09, Vol.53 (37), p.12497-12504
Main Authors: Kühn, Christian, Lindeberg, Gunnar, Gogoll, Adolf, Hallberg, Anders, Schmidt, Boris
Format: Article
Language:English
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Summary:1,3,5-syn substituted cyclohexane based amino acids have been prepared and incorporated into synthetic peptides to serve as scaffold mimicking the Val-Tyr-Ile sequence of angiotensin II. The conformationally constrained tripeptide mimetic holds potential use as a γ-turn replacement. Cyclohexane based turn mimetics have been incorporated into angiotensin II
ISSN:0040-4020
1464-5416
1464-5416
DOI:10.1016/S0040-4020(97)00779-5