Coevolution of longevity and female germline maintenance

An often-overlooked aspect of life-history optimization is the allocation of resources to protect the germline and secure safe transmission of genetic information. While failure to do so renders significant fitness consequences in future generations, germline maintenance comes with substantial costs...

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Published in:Proceedings of the Royal Society. B, Biological sciences Biological sciences, 2024-06, Vol.291 (2024), p.20240532
Main Authors: Baur, Julian, Koppik, Mareike, Savković, Uroš, Đorđević, Mirko, Stojkovic, Biljana, Berger, David
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Coleoptera - genetics
Coleoptera - physiology
Evolution
Female
Germ Cells
germline
life history
Longevity
Male
mutation rate
offspring quality
parental care
Reproduction
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Summary:An often-overlooked aspect of life-history optimization is the allocation of resources to protect the germline and secure safe transmission of genetic information. While failure to do so renders significant fitness consequences in future generations, germline maintenance comes with substantial costs. Thus, germline allocation should trade off with other life-history decisions and be optimized in accordance with an organism's reproductive schedule. Here, we tested this hypothesis by studying germline maintenance in lines of seed beetle, selected for early (E) or late (L) reproduction for 350 and 240 generations, respectively. Female animals provide maintenance and screening of male gametes in their reproductive tract and oocytes. Here, we reveal the ability of young and aged E- and L-females to provide this form of germline maintenance by mating them to males with ejaculates with artificially elevated levels of protein and DNA damage. We find that germline maintenance in E-females peaks at young age and then declines, while the opposite is true for L-females, in accordance with the age of reproduction in the respective regime. These findings identify the central role of allocation to secure germline integrity in life-history evolution and highlight how females can play a crucial role in mitigating the effects of male germline decisions on mutation rate and offspring quality.
ISSN:1471-2954
0962-8452
1471-2954
DOI:10.1098/rspb.2024.0532