LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans

Aim Liver‐expressed antimicrobial peptide 2 (LEAP2) dynamics in human plasma and its association with feeding behaviour remain poorly understood. Therefore, this study aims: (a) to investigate fasting LEAP2 in participants with normal weight or with overweight or mild obesity (OW/OB); (b) to study t...

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Published in:Diabetes, obesity & metabolism obesity & metabolism, 2024-10, Vol.26 (10), p.4734-4743
Main Authors: Andreoli, María F., Kruger, Ana Luz, Sokolov, Aleksandr V., Rukh, Gull, De Francesco, Pablo N., Perello, Mario, Schiöth, Helgi B.
Format: Article
Language:English
Subjects:
Adult
Antimicrobial Cationic Peptides
Antimicrobial peptides
Blood glucose
Blood Proteins
Body mass index
Dietary Proteins - administration & dosage
DNA Methylation
Fasting
Feeding behavior
Feeding Behavior - physiology
feeding behaviour
Female
Food intake
Genetic diversity
Genotyping
Humans
Impulsive Behavior
Impulsivity
LEAP2
Male
Middle Aged
Nutritional Status
Obesity
Obesity - blood
Obesity - genetics
Obesity - metabolism
Obesity - psychology
Overweight - blood
Overweight - genetics
Overweight - metabolism
Polymorphism, Single Nucleotide
Postprandial Period
Proteins
Reward
reward sensitivity
Sexual dimorphism
Single-nucleotide polymorphism
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Summary:Aim Liver‐expressed antimicrobial peptide 2 (LEAP2) dynamics in human plasma and its association with feeding behaviour remain poorly understood. Therefore, this study aims: (a) to investigate fasting LEAP2 in participants with normal weight or with overweight or mild obesity (OW/OB); (b) to study the association between fasting LEAP2 and anthropometric and metabolic traits, feeding behaviour, LEAP2 genetic variants and blood cell DNA methylation status; and (c) to ascertain postprandial changes in LEAP2 after high protein intake and the association with feeding behaviour and food intake. Methods Anthropometric and behavioural measures, genotyping, methylation profiling, plasma glucose and LEAP2 concentrations were assessed in 327 females and males. A subgroup of 123 participants received an ad libitum high‐protein meal, and postprandial LEAP2 concentration and behavioural measures were assessed. Results LEAP2 concentration was higher in participants with OW/OB (p 
ISSN:1462-8902
1463-1326
1463-1326
DOI:10.1111/dom.15850