Morphological Stability for in silico Models of Avascular Tumors

• Published in: Bulletin of mathematical biology 2024, Vol.86 (7), p.75, Article 75
• Main Authors: Blom, Erik, Engblom, Stefan
• Format: Article
• Language: English
• Subjects: Bayes Theorem; Bayesian analysis; Cell Biology; Cell population modeling; Computational tumorigenesis; Computer Simulation; Darcy's law; Emergent property; First principles; Humans; Life Sciences; Mathematical analysis; Mathematical and Computational Biology; Mathematical Concepts; Mathematical models; Mathematics; Mathematics and Statistics; Methods; Models, Biological; Neoplasms - pathology; Neovascularization, Pathologic - pathology; Partial differential equations; Precision medicine; Saffman-Taylor instability; Stability; Stochastic models; Stochastic Processes; Stochasticity; Systems Biology; Tumors
• ISSN: 0092-8240; 1522-9602; 1522-9602
• DOI: 10.1007/s11538-024-01297-x

The landscape of computational modeling in cancer systems biology is diverse, offering a spectrum of models and frameworks, each with its own trade-offs and advantages. Ideally, models are meant to be useful in refining hypotheses, to sharpen experimental procedures and, in the longer run, even for applications in personalized medicine. One of the greatest challenges is to balance model realism and detail with experimental data to eventually produce useful data-driven models. We contribute to this quest by developing a transparent, highly parsimonious, first principle in silico model of a growing avascular tumor. We initially formulate the physiological considerations and the specific model within a stochastic cell-based framework. We next formulate a corresponding mean-field model using partial differential equations which is amenable to mathematical analysis. Despite a few notable differences between the two models, we are in this way able to successfully detail the impact of all parameters in the stability of the growth process and on the eventual tumor fate of the stochastic model. This facilitates the deduction of Bayesian priors for a given situation, but also provides important insights into the underlying mechanism of tumor growth and progression. Although the resulting model framework is relatively simple and transparent, it can still reproduce the full range of known emergent behavior. We identify a novel model instability arising from nutrient starvation and we also discuss additional insight concerning possible model additions and the effects of those. Thanks to the framework’s flexibility, such additions can be readily included whenever the relevant data become available.