Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri

Three new dihydroflavonols, gloverinols A–C (1–3), a new flavon-3-ol, gloverinol D (4), two new isoflavans, gloveriflavan A (5) and B (6), and seven known compounds were isolated from the root bark of Dalbergia gloveri. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS da...

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Published in:Journal of natural products (Washington, D.C.) D.C.), 2024-09, Vol.87 (9), p.2263-2271
Main Authors: Kiganda, Ivan, Wieske, Lianne H. E., Nchiozem-Ngnitedem, Vaderament-Alexe, Chalo, Duncan, Umereweneza, Daniel, Ndakala, Albert, Herrebout, Wouter, Xiong, Ruisheng, Karpiński, Tomasz M., Yenesew, Abiy, Erdelyi, Mate
Format: Article
Language:English
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Summary:Three new dihydroflavonols, gloverinols A–C (1–3), a new flavon-3-ol, gloverinol D (4), two new isoflavans, gloveriflavan A (5) and B (6), and seven known compounds were isolated from the root bark of Dalbergia gloveri. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (2), gloveriflavan B (6), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone (10) were the most active against Staphylococcus aureus, with MIC values of 9.2, 18.4, and 14.2 μM, respectively.
ISSN:0163-3864
1520-6025
1520-6025
DOI:10.1021/acs.jnatprod.4c00690