Characterisation of a serine proteinase from Penaeus vannamei haemocytes

Serine proteinases are involved, besides digestive role, in immune response processes. In addition to the typical serine proteinase domain, proteinases from arthropod haemocytes contain so-called clip domains which are believed to exert regulatory functions. Clones coding for clip domain-containing...

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Bibliographic Details
Published in:Fish & shellfish immunology 2005-02, Vol.18 (2), p.101-108
Main Authors: Jimenez-Vega, F, Vargas-Albores, F, Soderhall, K
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Clip domain
Comparative Study
DNA Primers
Gene Expression Profiling
Gene Library
Hemocytes - chemistry
Litopenaeus vannamei
Marine
Molecular Sequence Data
Penaeidae - genetics
Penaeidae - metabolism
Penaeidae/genetics/metabolism
Penaeus monodon
Penaeus vannamei
Protein Structure, Tertiary
Sequence Alignment
Sequence Analysis, DNA
Serine Endopeptidases - blood
Serine Endopeptidases - genetics
Serine Endopeptidases - metabolism
Serine Endopeptidases/blood/genetics/metabolism
Serine proteinase
Shrimp immunity
Species Specificity
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Summary:Serine proteinases are involved, besides digestive role, in immune response processes. In addition to the typical serine proteinase domain, proteinases from arthropod haemocytes contain so-called clip domains which are believed to exert regulatory functions. Clones coding for clip domain-containing serine proteinases were isolated from both Penaeus vannamei and Penaeus monodon haemocyte cDNA libraries. These proteins have most of the structural characteristics of serine proteinase domain, but in the clip domain there are only four cysteines, whereas in most other clip domains there are six. Such structures are named pseudo-clip domains and apparently seem to be widely distributed in Penaeid shrimp. These proteinases were only expressed in haemocytes and not in muscles, hypodermis, heart, tail stalk, pleopods or hepatopancreas.
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2004.02.001