Toxicity in standard melphalan–prednisone therapy among myeloma patients with renal failure – a retrospective analysis and recommendations for dose adjustment

Summary Haematological and infectious toxicity was correlated to renal function in 272 newly diagnosed myeloma patients given standard dose melphalan–prednisone (MP) as initial treatment without dose adjustment for renal impairment. The glomerular filtration rate (GFR) was estimated by calculated cr...

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Bibliographic Details
Published in:British journal of haematology 2005-03, Vol.128 (5), p.631-635
Main Authors: Carlson, Kristina, Hjorth, Martin, Knudsen, Lene Meldgaard
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
Biological and medical sciences
Drug Administration Schedule
Female
glomerular filtration rate
Glomerular Filtration Rate - drug effects
Hematologic and hematopoietic diseases
Hematology
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - drug therapy
Kidney Failure, Chronic - mortality
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Melphalan - adverse effects
melphalan–prednisone
Middle Aged
multiple myeloma
Multiple Myeloma - complications
Multiple Myeloma - drug therapy
Multiple Myeloma - mortality
Multiple Myeloma/complications/drug therapy/mortality
Prednisone - adverse effects
Prednisone - therapeutic use
Prednisone/adverse effects/therapeutic use
renal failure
Retrospective Studies
Survival Rate
toxicity
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Summary:Summary Haematological and infectious toxicity was correlated to renal function in 272 newly diagnosed myeloma patients given standard dose melphalan–prednisone (MP) as initial treatment without dose adjustment for renal impairment. The glomerular filtration rate (GFR) was estimated by calculated creatinine clearance. Haematological toxicity was found to be significantly related to renal dysfunction. Haematological toxicity World Health Organization (WHO) grades 3–4 after the first MP course was seen in 18%, 28% and 36% of patients with a creatinine clearance of >50, 30–50 and
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2005.05366.x