Effect of rosuvastatin or atorvastatin on urinary albumin excretion and renal function in type 2 diabetic patients

The effect of rosuvastatin or atorvastatin on urinary albumin excretion (UAE) was determined in type 2 diabetic patients. A randomized, double-blind, parallel-group, response-based design compared rosuvastatin 10 mg (titrated to 40 mg) with atorvastatin 10 mg (titrated to 80 mg) in type 2 diabetic p...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2006-04, Vol.72 (1), p.81-87
Main Authors: Sorof, Jonathan, Berne, Christian, Siewert-Delle, Annica, Jørgensen, Leif, Sager, Philip
Format: Article
Language:English
Subjects:
Aged
Albuminuria
Atorvastatin Calcium
Diabetes mellitus type II
Diabetes Mellitus, Type 2 - physiopathology
Diabetes Mellitus, Type 2 - urine
Double-Blind Method
Female
Fluorobenzenes - therapeutic use
Glomerular Filtration Rate
Heptanoic Acids - therapeutic use
Humans
Hydroxymethylglutaryl-CoA reductase inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Kidney Function Tests
Male
Middle Aged
Pyrimidines - therapeutic use
Pyrroles - therapeutic use
Rosuvastatin Calcium
Sulfonamides - therapeutic use
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Summary:The effect of rosuvastatin or atorvastatin on urinary albumin excretion (UAE) was determined in type 2 diabetic patients. A randomized, double-blind, parallel-group, response-based design compared rosuvastatin 10 mg (titrated to 40 mg) with atorvastatin 10 mg (titrated to 80 mg) in type 2 diabetic patients with dyslipidemia, with dose titration to an LDL-C target of 20 μg/min). No significant change in GFR from baseline after 16 weeks was observed for either treatment group. These data provide reassurance that type 2 diabetic patients can be treated with higher efficacy statins without clinically meaningful effects on urinary albumin excretion.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2005.09.004