Insulin resistance, dietary fat intake and blood pressure predict left ventricular diastolic function 20 years later

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2005-08, Vol.15 (4), p.242-249
• Main Authors: Ärnlöv, Johan, Lind, Lars, Sundström, Johan, Andrén, Bertil, Vessby, Bengt, Lithell, Hans
• Format: Article
• Language: English
• Subjects: Aged; Blood Glucose - metabolism; Blood pressure; Blood Pressure - physiology; Cholesterol Esters - analysis; Cholesterol Esters - chemistry; Cholesterol Esters/analysis/chemistry; Cohort Studies; Cross-Sectional Studies; Diastolic function; Diet Records; Dietary fat; Dietary Fats - administration & dosage; Dietary Fats - metabolism; Dietary Fats/administration & dosage/metabolism; Echocardiography; Fatty Acids - analysis; Follow-Up Studies; Glucose Clamp Technique; Health Surveys; Heart; Heart Rate; Humans; Insulin Resistance; Longitudinal Studies; Male; Middle Aged; Predictive Value of Tests; Sweden; Ventricular Dysfunction, Left - epidemiology; Ventricular Dysfunction, Left - etiology
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2004.10.002

Our knowledge on the development of left ventricular diastolic dysfunction is scarce. Thus, we aimed to investigate the relationship between left ventricular diastolic function and a wide variety of cardiovascular risk factors, including dietary factors using both cross-sectional and longitudinal data with 20 years follow-up. A population-based cohort of 505 50-year-old men was examined with determinations of blood pressure, insulin, glucose and fatty acid composition of serum cholesterol esters. A reinvestigation 20 years later also included hyperinsulinaemic euglycaemic clamp, 7-day diet record and Doppler echocardiography with determination of left ventricular diastolic function (early (E) and late (A) peak mitral velocities and left atrial diameter). Blood pressure both at age 50 and 70 was negatively correlated to the E/A ratio ( r=−0.15, p