Prevention of periarticular heterotopic ossification following total hip arthroplasty. Clinical experience with indomethacin and ibuprofen

Prophylactic treatment with indomethacin or ibuprofen to prevent periarticular heterotopic ossification (PHO) was investigated in a consecutive series of 200 total hip replacements (THR) performed for primary coxarthrosis in 170 patients. No widespread PHO (grades III and IV) occurred in 166 THR tre...

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Bibliographic Details
Published in:Archives of Orthopaedic and Traumatic Surgery 1988-01, Vol.107 (6), p.329-333
Main Authors: Sodemann, B, Persson, P E, Nilsson, O S
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Female
Hip Prosthesis - adverse effects
Humans
Ibuprofen - therapeutic use
Indomethacin - adverse effects
Indomethacin - therapeutic use
Male
Middle Aged
Ossification, Heterotopic - prevention & control
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Summary:Prophylactic treatment with indomethacin or ibuprofen to prevent periarticular heterotopic ossification (PHO) was investigated in a consecutive series of 200 total hip replacements (THR) performed for primary coxarthrosis in 170 patients. No widespread PHO (grades III and IV) occurred in 166 THR treated with indomethacin or ibuprofen from the 1st to the 21st postoperative day. Only one patient exhibited moderate (grade-II) ossification. In contrast, the incidence of PHO grades III and IV was found to be high (23%) in the 35 THR for which the patients did not receive prophylaxis according to intention. It was concluded that 3 weeks' postoperative treatment with indomethacin or ibuprofen is sufficient to prevent the development of clinically significant heterotopic ossification.
ISSN:0344-8444
0936-8051
1434-3916
DOI:10.1007/BF00381057